Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pathology II > LEC 13 - GI IV > Flashcards

LEC 13 - GI IV Flashcards

1
Q

How do animals become infected with Group A rotavirus?

A

Orally

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What does Group A rotavirus target in the body?

A

villus enterocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are clinical hallmarks of a Group A rotavirus infection?

A

Yellow-watery diarrhea

Dehydration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

When are calves susceptible to Group A rotavirus?

A

first week of age

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

When are piglets susceptible to group A rotavirus infections?

A

First 7 weeks of life

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What secretory enterotoxin is produced by Group A rotavirus?

A

NSP4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the pathogenesis of group A rotavirus infection?

A

Upper 2/3 of villi are affected

Necrosis of epithelium

Shortening + fusion of villi

Virus produces NSP4 increasing Cl- secretion

Blocks Na/Glu cotransporter

Malabsorptive + Secretory diarrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the pathogenesis of coronavirus enteritis?

A

Crypt epithelium can be hyperplastic + necrotic

Crypt abscesses form

Characterized by necrotic cellular debris dilating crypts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What animals are affected by adenoviral enteritis?

A

Cattle

Sheep

Pig

Goat

Ibex

Cervids

Horses

Breaded dragons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

In Arabian horses what does adenovirus infections associate with?

A

Combined immunodeficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How is adenovirus transmitted?

A

Aerosol

Fomites

Feces

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What cell type does adenovirus target?

A

Epithelium endothelium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What occurs to the villus with an adenovirus infection?

A

Loss

Villus blunting + Fusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the histopathological signs of an adenovirus infection?

A

Basophilic to amphophilic intranuclear inclusion bodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What animals are most affected by E. Coli?

A

Young Animals

Pigs + Calves

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q
  • What are the determining factors that determine if an e. coli infection shows disease?
A

Genetic make-up

Passive transfer

Milk-associated antibodies

Environmental contamination/stressors

Concurrent infections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What are the five forms of e. coli?

A

ETEC

EIEC

EHEC

EPEC/AEEC

Edema disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Describe: ETEC

A

Enterotoxic/enterotoxigenic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Describe: EIEC

A

Specticemic/Enteroinvasive

20
Q

Describe: EHEC

A

Enterohemorrhagic

21
Q

Describe: EPEC/AEEC

A

Enteropathogenic/Attaching + Effacing

22
Q

Describe: Edema disease

A

Enterotoxemic

23
Q

How do all e. coli attach to cells?

A

Pili

– or –

Fimbriae

24
Q

What toxins do e. coli produce?

A

Enterotoxin

– and –

Shigatoxin

25
Q

What age is most affected by ETEC?

A

2 days to 3 weeks

26
Q

What animals are most commonly infected by ETEC?

A

Calves

Piglets

27
Q

What does ETEC cause?

A

Secretory diarrhea

28
Q

How does ETEC cause secretory diarrhea?

A

Endotoxin induced Na/Cl secretion into lumen by affecting cGMP and CGAMP dependent kinase

29
Q

What animals are infected by EIEC?

A

Newborn calves + lambs

Occasionally foals

30
Q

What is the pathogenesis of EIEC?

A

Bacteria enter umbilicus + oral cavit + Respiratory

Multisystemic inection

Fibrin deposition + Neutrophilic inflammation

31
Q

What animals are susceptible to edema disease?

A

Pigs

Between 6 to 14 weeks

Dietary changes at weaning

32
Q

What does the bacteria responsible for edema disease produce?

A

Verotoxin

33
Q

What is the characteristic signs of edema disease?

A

Neurologic signs

Incoordination + Poor balance + Weakness + Tremors

34
Q

What is the pathogenesis of Edema disease?

A

Bacteria proliferate in NI

Produce angiotoxin

Causes vascular endothelial injury of arteries

Fluid loss + Edema

35
Q

What is often the cause of EHEC infection?

A

Contaminated ground beef

Not a naturally occurring disease

36
Q

What is the pathogenesis of EHEC?

A

Bacteria produces a shiga-toxin

Contains plasmid encoding for hemolysin

Produces hemorrhagic colitis

37
Q

What animals does EPEC/AEEC infect?

A

Rabbits

Calves

Pigs

Lambs

Dogs

Humans

38
Q

What gross lesions are present with EPEC/AEEC?

A

Dilated + Fluid filled intestinal tract

39
Q

How does pathogenesis of EPEC/AAEC occur?

A

Intimin facilitates attachment to enterocytes

Effacement of surface microvilli + alters tight junction proteins

Loss of glycocalyx

40
Q

What does EPEC/AAEC cause?

A

Maldigestion

Malabsorption

Diarrhea

41
Q

What is the second most common food borne pathogen?

A

Salmonella Typhurium

42
Q

What are the serovars of salmonella seen in animals?

A

Typhimurium

Cholerasuis

Enterica

Dublin

Typhosa

43
Q

What are the three forms of salmonellosis?

A

Peracute

Acute

Chronic

44
Q

What is different about Salmonella Typhimurium + Cholerasuis?

A

Produced toxins blocked closure of Cl channels

Result in secretory diarrhea + malabsorption

45
Q

What is the pathogenesis of a Salmonella infection?

A

Fecal-oral entry

Survive phagosome environment by producing nitrate transporter

Neutralizes NO

Colonize regional lymph nodes

Systemic

46
Q

What toxins does Salmonella produce?

A

Enterotoxins

Endotoxins

Cytotoxins

47
Q

What can cause Peracute Salmonella septicemia?

A

Cholerasuis

Pathology II (20 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions