Lead Poisoning Flashcards
Important roles of metals
Cofactors in oxidation and reduction rxns
Essential minerals
Zn, Se, Cu, Fe, Co, Mn, Cr
Major inhibitory toxic metals
Arsenic, mercury, cadium, lead
Chealtors
EDTA, BAL, penicillamine, Defereoxamine, succimer
Lead mechanism of toxicosis
Binds sufhydryl groups in enzymes
Competes and replaces zinc
Affects all organs
Lead exposure susceptibility
Oral, inhalation, contact surfaces, in-utero, milk
Affects young animals, children, cattle and dogs mostly
Lead common sources
Used motor oil
Drapery weights/ tire weights
Batteries/ fishing sinkers
Newspaper print
Improperly glazed pottery
Roofing felt
Automotive machinery
Lead target organs
Nervous system
Hematopoietic system
GI tract
Reproductive, immune, kidney
Lead hematopoietic toxicity
Inhibits heme synthesis → accumulation of heme precursors in blood
Lead hematopoietic effects
Anemia (microcytic, hypochromic)
↑ reticulocytes, RBC fragility
Shortened lifespan
BM depression
Lead GIT toxicosis
Mild gastritis or enteritis
Esophageal dilatation
Lead renal intranuclear inclusions
Eosinophilic dense homogenous bodies (lead protein complex)
Acid fact with carbolfuschsin
How does lead affect the reproduction system
Abortions, resorptions, sterility, retardation
Lead affected respiratory system
Inspiratory dyspnea
Respiratory paralysis (roaring)
Nervous system lead effects
Head bobbing, head pressing, twitching of the ears, muscle tremors, seizures, segmental demyelination
