LE-4-Renal-Physiology-Feed-Batch-2025 Flashcards
- Which of the following statements is true regarding the nephron:
A. nephron’s concentrating ability is greatest in the cortex
B. the cortical collecting duct is not part of the nephron segment
C. the number of mitochondria increases as the nephron segments dip into the medulla
D. superficial nephrons are greater in number than JG nephrons
B. the cortical collecting duct is not part of the nephron segment
- Which of the following statements is true regarding the renal corpuscle
A. the macula densa of the thick ascending limb is part of the renal corpuscle
B. water and solute filtration from the peritubular capillaries becomes the ultrafiltrate in the renal corpuscle
C. the peritubular capillaries provides the structural support of the renal corpuscles
D. peritubular capillary hydrostatic pressure promotes filtration in the renal corpuscle
C. the peritubular capillaries provides the structural support of the renal corpuscles
- The following statements are true of the renal mesangium EXCEPT:
A. the mesangium may regulate protein filtration
B. mesangial cells may regulate GFR
C. the mesangial cells possess phagocytic properties
D. mesangial cells secretes extracellular matrix
B. mesangial cells may regulate GFR
- Which of the following statements is NOT considered a basic process of urine formation in man?
A. maintenance of normal acid base by the renal tubules
B. solute secretion into the tubular fluid by the renal tubules
C. Option 2
D. plasma filtration by the glomerulus
E. solute and water reabsorption by the renal tubules
A. maintenance of normal acid base by the renal tubules
- Which of the following solutes are reabsorbed via a symport mechanism in the apical membrane of the proximal tubules?
A. Na – glucose
B. hydrogen -ATPase
C. Na -hydrogen
D. Na/K ATPase
A. Na – glucose
Sodium-Potassium ATPase (Antiporter)
Sodium-Chloride Symporter
Secondary Active Transport
* Sodium-Glucose Cotransporter (SGLT-2) : Symporter
* Sodium/AA Cotransporter
* Sodium-Lactate Cotransporter
- The uphill movement of hydrogen ions across the renal cells is via this mechanism
A. facilitated diffusion
B. active transport
C. coupled transport
D. secondary active transport
D. secondary active transport
- Which of the following is a major
determinant of ECF osmolality?
A. H20
B. Na
C. Cl
D. HCO3
B. Na
- Which of the following choices partly
explains the uneven distribution of Na and K
in the ECF and ICF compartments?
A. K is actively secreted into the tubular fluid across the apical membrane
B. Cl channels reabsorbed Na in exchange for K+ ions
C. Na- K ATPase activity maintains Na+ and K+ ion movements across membranes
D. Na is actively reabsorbed into the cell by the sodium – hydrogen exchangers in the apical membrane
C. Na- K ATPase activity maintains Na+ and K+ ion movements across membranes
- A more accurate estimation of plasma
osmolality can be achieved by considering
the concentration of which substances?
A. bicarbonate and NH4
B. inorganic phosphates
C. chloride and water
D. glucose and urea
D. glucose and urea
- Which of the following statements regarding sodium reabsorption in the proximal tubules is correct?
A. the electronegativity of the tubular fluid in the PCT may enhance sodium reabsorption
B. sodium reabsorption is coupled with
chloride in the 1st half of the proximal tubule
C. a decreased hydrostatic pressure in
the peritubular capillaries of the PCT
increases sodium reabsorption
D. the sodium ions may diffuse across the
apical membrane of the first half of the
proximal tubules
C. a decreased hydrostatic pressure in the peritubular capillaries of the PCT increases sodium reabsorption
In the proximal half of the PCT, transcellular transports only occurs here such as when: Na+ is reabsorbed in exchange with H+ and it is cotransported with lactate, glucose, and the likes. Reabsorption of Cl- does not occur here, however, remember that when Na+ is reabsorbed Cl- goes with it— but in the first half of the PCT no reabsorption of Cl- happens such that the Cl- conc. in the filtrate becomes high. Thus, Cl- concentration is very high, this is why in the second half, reabsorption of Cl- occurs.
- Sodium chloride reabsorption in the 2nd
half of the PCT is increased due to which of
the following choices?
A. intracellular chloride concentration in the
first half of the PCT is greater than in the
tubular fluid
B. Na+ K+ ATPAse pump activity is greater
in the 2nd half of the PCT
C. The chloride concentration renders the
tubular fluid to become more positively
charged
D. Chloride concentration in the tubular
fluid is increased in the 1st half
D. Chloride concentration in the tubular fluid is increased in the 1st half
In the proximal half of the PCT, transcellular transports only occurs here such as when: Na+ is reabsorbed in exchange with H+ and it is cotransported with lactate, glucose, and the likes. Reabsorption of Cl- does not occur here, however, remember that when Na+ is reabsorbed Cl- goes with it— but in the first half of the PCT no reabsorption of Cl- happens such that the Cl- conc. in the filtrate becomes high. Thus, Cl- concentration is very high, this is why in the second half, reabsorption of Cl- occurs.
- A transtubular osmotic gradient allows
the passive reabsorption of water across
membranes in the PCT. This movement
can be due to which of the following? A
high________ reabsorption in the PCT
A. hydrogen
B. glucose
C. Cl
D. Na
D. Na
In the proximal half of the PCT, transcellular transports only occurs here such as when: Na+ is reabsorbed in exchange with H+ and it is cotransported with lactate, glucose, and the likes. Reabsorption of Cl- does not occur here, however, remember that when Na+ is reabsorbed Cl- goes with it— but in the first half of the PCT no reabsorption of Cl- happens such that the Cl- conc. in the filtrate becomes high. Thus, Cl- concentration is very high, this is why in the second half, reabsorption of Cl- occurs.
- As hydrostatic pressure in the paracellular spaces of the PCT increases, which of the following choices will occur?
A. increase the osmotic pressure in the tubular fluid
B. move towards the tubular fluid
C. move towards the capillaries
D. increase the hydrostatic pressure in the tubular fluid decreases
C. move towards the capillaries
Transport of water and solutes from the interstitial fluid into the peritubular capillaries occurs by ultrafiltration (bulk flow) that is mediated by hydrostatic and colloid osmotic forces.
- Organic cations and anions are eliminated by the kidney via
A. glomerular filtration of anions and cations as part of ultrafiltrate
B. secretion of anions and cations by cells of the PCT
C. absorption of anions and cations by the vasa recta
D. absorption of cations by the renal calyces
B. secretion of anions and cations by cells of the PCT
- Which of the following true regarding renal handling of Para aminohippuric acid or PAH)
A. PAH secretion PCT is via a PAH-cation Transporter
B. organic anions compete for the same transporters
C. PAH is reabsorbed thru the basolateral membrane
D. as PAH levels increases, other cations increase
B. organic anions compete for the same transporters
- Which of the following statements is correct regarding the loop of Henle
A. water reabsorption in the loop of henle is iso-osmotic
B. most of the active reabsorption of filtered solutes occur
C. solutes are absorbed as tubular fluid enters the TAL
D. It also acts as the countercurrent exchanger in the DCT
C. solutes are absorbed as tubular fluid enters the TAL
- Regarding the calcium paradox, which of the following detects the low Ca concentration that leads to renin release?
A. Efferent arterioles
B. Afferent arterioles
C. Granular cells
D. Macula densa
C. Granular cells
- As the Na-K ATPase pump activity in the TAL increases, this will lead to:
A. decreased Na-H antiporter activity at the apical membrane
B. decreased K ion concentration inside the cell
C. establishment of a chemical gradient for Na+ secretion
D. a low intracellular Na concentration
D. a low intracellular Na concentration
- The 1Na+ -1K+ -2Cl transporter in the apical membrane of the TAL is important due to the following:
A. it increases tubular fluid flow in the DCT
B. it contributes to the decreasing osmolality of the tubular fluid of the TAL
C. it increases solute concentration in the tubular fluid
D. it contributes to the increased absorption of urea in the TA
B. it contributes to the decreasing osmolality of the tubular fluid of the TAL
- When the kidneys autoregulate, which of the following will be maintained?
A. RAAS activation
B. GFR
C. ADH secretion
D. tubular fluid osmolarity
B. GFR
- If the delivery of NaCl in Macula densa is high, renin secretion will be
A. High
B. Unchanged
C. Influenced by ADH
D. Low
D. Low
- The concept of the Calcium paradox applies to which of the mechanisms below?
A. Countercurrent exchange
B. Countercurrent multiplication
C. Urea recycling
D. Renal autoregulation
D. Renal autoregulation
- Which of the following is not absorbed in the PCT?
A. Na
B. K
C. HCO3
D. hydrogen
D. hydrogen
- Water reabsorption is least likely to occur in the:
A. PCT
B. DTL
C. CCD
D. TAL
D. TAL
- Which of the following completely absorbed in the PCT?
A. Ascorbic acid
B. Glucose
C. Na
D. K
B. Glucose
- Which of the following choices below is true about renal blood flow? Renal blood flow INCREASES when:
A. there is activation of the RAAS system
B. afferent arterioles are vasodilated
C. blood flow in afferent arteriole falls
D. JG apparatus releases a vasodilator
B. afferent arterioles are vasodilated
- For fluid resuscitation to occur, which of the following will restore blood volume faster?
A. Polycationic dextran
B. Neutral dextran
C. 0.9 NaCl
D. Polyanionic dextran
D. Polyanionic dextran
- Increases in renal blood flow and ang GFR are caused by:
A. Increased plasma colloid pressure
B. Increased glomerular capillary coefficient
C. Afferent arteriolar dilation
D. Efferent arteriolar dilation
C. Afferent arteriolar dilation
- The maximum clearance rate for a substance that is totally cleared from the plasma is equal to:
A. GFR
B. Urinary excretion
C. Renal plasma flow
D. Filtered load of that substance
C. Renal plasma flow
- At the tip of the 2nd half of the proximal tubule you expect this ion to be present IN high concentration
A. Protein
B. k
C. Na
D. HCO3
C. Na
- A patient suffering from glomerulonephritis with decrease in GFR you expect which of the choices below to increase in the plasma?
A. Na
B. K
C. Creatinine
D. Glucose
C. Creatinine
- Regarding Renal blood flow which of the following is a correct statement?
A. Oxygen extraction is higher in the cortex than the medulla
B. Angiotensin II causes greater constriction of the efferent than the afferent arteriole
C. Glomerular capillaries drain into peritubular veins
D. Renal autoregulation is prevented by denervation
B. Angiotensin II causes greater constriction of the efferent than the afferent arteriole
- Which of the following best describes the juxtaglomacular apparatus
A. Contains juxtamglomerular cells in the afferent arterioles only
B. Contains macular densa cells in afferent and efferent arterioles
C. Responds to a fall in arterial pressure by increasing renin secretion
D. Responds to an increase in Na concentration by increasing GFR
C. Responds to a fall in arterial pressure by increasing renin secretion
- Which of the following may increase filtration fraction?
A. Glomerular capillary hydrostatic pressure
B. Afferent arteriolar resistance
C. Glomerular capillary oncotic pressure
D. Efferent arteriolar hydrostatic pressure
A. Glomerular capillary hydrostatic pressure
- Activation of renal sympathetics may INCREASE:
A. the hydraulic pressure in the DCT
B. the hydraulic pressure in the glomerulus
C. Na reuptake in the proximal tubules
D. Na secretion in the proximal tubules
C. Na reuptake in the proximal tubules
- Regarding UREA recycling this is best described by which of the following?
A. maintains the osmolarity of the medullary interstitium
B. half of filtered urea enters the descending thin limb
C. lowers the osmolarity of the plasma in the vasa recta
D. actively reabsorbs urea in the distal convoluted tubules
B. half of filtered urea enters the descending thin limb
- During countercurrent multiplication, as urea descends thru the collecting ducts, which of the following may occur?
A. Most urea is reabsorbed
B. 50 % is lost in the urine
C. Most of the urea enters the vasa recta
D. 100 %is lost in the urine
A. Most urea is reabsorbed
- During countercurrent multiplication, a hyper osmolar medullary interstitium ensures that:
A. water is volume is high in the CCD
B. solutes are returned back into the vasa recta
C. solute concentration is high in the medulla
D. water is reabsorbed in the DTL and CCD
D. water is reabsorbed in the DTL and CCD
- In a dehydrated individual, the secretion of ADH is elevated and
A. the medullary interstitium is hyperosmotic
B. the solute and water movement in the PCT is iso osmotic
C. the DCT is impermeable to water
the tubular fluid in the CCD is hyperosmotic
A. the medullary interstitium is hyperosmotic
- Which of the following statements is true regarding the ASCENDING limb of the vasa recta?
A. Blood flow in the ascending limb turbulent
B. Blood flow in the ascending limb is high
C. It looses the solutes as plasma passes along it
D. It looses the water as plasma passes along it
C. It looses the solutes as plasma passes along it