Large Animal Loco-Regional Anaesthesia Flashcards
What different drugs can be used in loco-regional anaethesia ?
- Local anaestheticsq
- Opioids
- Alpha 2 agonists
Wha relevance of ionisation of tissue when admin of local?
how quick they bind depends on pH of drug/tissue
if pKa lower than 8.9 -> long time to action
What determinants of duration of action ?
- Protein Binding
- Vasomotor Activity
Explain protein binding?
Inc protein binding -> slower systemic uptake -> longer duration of action
Vasomotor Activity - explain
Most locals cause some vasoD (exception: cocaine, bupivacaine, ropivicaine)
Vasodilation -> faster systemic uptake -> shorter duration of action
by adding vasoconstriction drug (e.g.epinephrine) will last longer because of slower systemic uptake
Describe toxicity with increasing dose of local?
which local in what species?
When would we use opioids?
Morphine (horses only)
- Epidural
- Intra-articular
Use of alpha 2 as local?
Xylazine or detomidine
What types of loco-regional anaesthetics ?
Topical
Local - around nerve or as a ring block/perinural
Regional - admin distant from surgical site creating whole anaesthetised region
What locations to consider in equine head ?
What locations in ruminants?
What Local areas for dehorning?
Castrate block?
Intra-testicular black
What is an example of regional block?
Epidural
What potential complications with epidural?
Inadvertent Intra-thecal Injection
Hypotension
Motor Block
Urinary Retention (morphine)
Neurological Injury
Drugs (e.g. preservatives, adrenalin)
Infection, Haematoma, Trauma