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Exam 1: DHHD 5002 > Lam 1 > Flashcards

Lam 1 Flashcards

1
Q

Chemical make up, molecular configuration

A

Chemical name

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2
Q

Proprietary (brand) name adopted by a manufacturer

A

Trade name (patented)

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3
Q

Non-proprietary name assigned and approved by the United States Adopted Name Council.

A

Generic name (official)

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4
Q

What the body does to the drug, affects time to onset of effect, intensity, and duration

A

Pharmcokinetics

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5
Q

A.D.M.E.

A

Absorption
Distribution
Metabolism
Excretion

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6
Q

What the drug does to the body, interaction (ion channels, etc.), effector mechanisms, dose-response

A

Pharmacodynamics

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7
Q

Drug and Action for Bronchospasm (Severe Allergic Reaction)

A
  • Epinephrine

- a and B adrenergic receptor agonist

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8
Q

Drug and Action for Mild Allergic Reaction

A
  • Diphenhydramine

- Histamine blocker

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9
Q

Drug and Action for Angina

A
  • Nitroglycerin

- Vasodilator

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10
Q

Drug and Action for Bronchospasm (Mild Asthma)

A
  • Albuterol (bronchodilator)

- Selective B2-adrenergic receptor agonist

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11
Q

Does drug create new biological effects?

A

No

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12
Q

Drugs (indirectly/directly) stimulate or suppress cellular function.

A

Directly

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13
Q

Drugs enhance or block action of an _______ or another foreign compound.

A

endogenous ligand

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14
Q

Affected by affinity of drug to target

A

Potency

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15
Q

Affected by ability of drug-target interaction to initiate a response

A

Efficacy

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16
Q

Dose or concentration needed to produce E50 (50% of max. response or Emax)

A

Potency

17
Q

The lower the dose or concentration, the _____ the potency.

A

Greater

18
Q

Magnitude of response

A

Efficacy

19
Q

Drug producing _____ maximal effect is more efficacious.

A

greater

20
Q

Activates mu receptor and produces maximum biological response

A

Full agonist

21
Q

Submaximal response

A

Partial agonist

22
Q

Does response curve shifted to right

A

Competitive antagonist

23
Q

Opposite response

A

Inverse agonist

24
Q

Reduction in response to a drug, shift of dose-response curve to right

A

Drug tolerance

25
Q

Pharmacodynamic basis for altered drug response

A
  • Decrease in receptor number

- Decrease in efficiency of signal transduction system

26
Q

Pharmacokinetic basis for altered drug response

A
  • Increased metabolism

- Increased dose

27
Q

Shift dose response curve to left

A
  • Decreased ED50

- Increased potency

28
Q

Additive effect

A

combined effect = sum of individual effect

29
Q

Synergistic effect

A

combined effect > sum of individual effect

30
Q

Therapeutic Index

A

TD50/ED50, safety margin

31
Q

Therapeutic dose in 50% of individuals

A

Median ED50

32
Q

Toxic dose in 50% of individuals

A

Median TD50

Exam 1: DHHD 5002 (23 decks)

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