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BMS381 - Neurodevelopment > L9 - Addiction > Flashcards

L9 - Addiction Flashcards

1
Q

Opiate receptors

A

u opiate

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2
Q

nicotine receptors

A

acetylcholine

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3
Q

cannabis receptors

A

cannaboid

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4
Q

alcohol receptors

A

several including; - GABA and NDMA

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5
Q

secondary target of drugs

A

mesolimbic system - dopamine

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6
Q

dopamine release

A

ventral tegmental area neurons

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7
Q

mesolimbic pathway

A

natural rewards from sex, food, social interaction

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8
Q

Dopamine action on

A

dopamine and serotonin pathways

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9
Q

Drug addiction contributing factors

A

genetics
social environment
personality and personal history

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10
Q

sensitivity

A

inability to tolerate the adverse effects of a drug

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11
Q

tolerance

A

reduction in sensitivity when drug is used repeatedly

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12
Q

model organism for drug addiction

A

drosophila

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13
Q

human disease suited for analysis in drosophila

A

cancer
developmental, metabolic and neurological disorders,
cardiovascular disease

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14
Q

drug receptors lacking in flies

A

opioid

cannaboid

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15
Q

experimental approaches to measure ethanol effects on flies

A

booz-o-mat

inebriometer

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16
Q

movement of flies exposed to ethanol

A

immediate phase - increased locomotion

over time - slow down until sedation

17
Q

elution of flies exposed to ethanol

A

fast

18
Q

ethanol sensitivity on alcoholism

A

low sensitivity increases future risk of alcoholism

19
Q

technique to identify genes implicated in sensitivity

A

induce mutations, measure elution times,

identify fastest flies

20
Q

cheapdate mutant

A

increased ethanol sensitivity

21
Q

gene mutated in cheapdate

A

allele of amnesiac

22
Q

amnesiac

A

neuropeptide

23
Q

amnesiac function

A

activates cAMP pathway

24
Q

mutation in cheapdate

A

reduces downstream transcription due to inactivation of CREB

25
Q

cAMP activity

A

decreases alcohol sensitivity

26
Q

technique to measure tolerance

A

repeat inebriometer test,

tolerance indicated by longer elution time

27
Q

hangover

A

encodes zn-finger - acts as TF

28
Q

hangover effect on cAMP

A

speeds up cAMP inactivation

29
Q

what promotes development of tolerance

A

faster deactivation of cAMP pathway

30
Q

chronic alcohol exposure

A

increases HPA activity - elevated glucocorticoid levels

BMS381 - Neurodevelopment (15 decks)

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