L13 - Reprogramming Flashcards

1
Q

Reprogramming occurs

A

when axons encounter intermediate targets

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2
Q

Commissural axon responsiveness netrin

A

lost post midline

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3
Q

Semaphorins

A

inhibitory molecule

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4
Q

Slits

A

inhibitory molecule

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5
Q

Genetic screens in drosophila

A

identified robo and comm

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6
Q

Slit receptor levels determine

A

whether axons cross the midline

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7
Q

Comm regulates

A

robo expression

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8
Q

Robo regulation models

A

sorting and clearance

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9
Q

Correct model

A

sorting

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10
Q

Robo expression pre-crossing

A

low

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11
Q

Robo expression post crossing

A

high

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12
Q

TAG1 expression

A

pre-crossing axons

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13
Q

Slit function

A

binding stabilises ROBO

inhibits netrin

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14
Q

Silencing of Netrin response by slit

A

interaction between cytoplasmic domains of DCC and robo

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15
Q

Switch in sensitivity

A

contact with floor plate

Par complex

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16
Q

Shh function

A

guides commissural axons to floor plate