L13 - Reprogramming Flashcards
1
Q
Reprogramming occurs
A
when axons encounter intermediate targets
2
Q
Commissural axon responsiveness netrin
A
lost post midline
3
Q
Semaphorins
A
inhibitory molecule
4
Q
Slits
A
inhibitory molecule
5
Q
Genetic screens in drosophila
A
identified robo and comm
6
Q
Slit receptor levels determine
A
whether axons cross the midline
7
Q
Comm regulates
A
robo expression
8
Q
Robo regulation models
A
sorting and clearance
9
Q
Correct model
A
sorting
10
Q
Robo expression pre-crossing
A
low
11
Q
Robo expression post crossing
A
high
12
Q
TAG1 expression
A
pre-crossing axons
13
Q
Slit function
A
binding stabilises ROBO
inhibits netrin
14
Q
Silencing of Netrin response by slit
A
interaction between cytoplasmic domains of DCC and robo
15
Q
Switch in sensitivity
A
contact with floor plate
Par complex
16
Q
Shh function
A
guides commissural axons to floor plate
