L1 - Intro Flashcards

1
Q

When does neural patterning and neurogenesis occur in humans

A

4-12 weeks

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2
Q

How do cells become more specialised?

A

changes in gene expression

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3
Q

What is gene expression governed by?

A

extrinsic factors - morphogens

intrinsic factors - transcription factors

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4
Q

What causes the AP axis regionalisation of the neural tube?

A

Retinoic acid gradient

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5
Q

What does the retinoic acid gradient induce?

A

different patterns of Hox transcription factors

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6
Q

What does in situ hybridisation detect?

A

mRNA

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7
Q

What is Shh?

A

morphogen

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8
Q

What axis does Shh pattern?

A

DV

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9
Q

What does the transcription factor code dictate?

A

later differentiation

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10
Q

What establishes progenitor domains in the spinal cord?

A

opposing gradients of Shh and BMPs/Wnts

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11
Q

Which way do neural crest cells migrate?

A

laterally

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12
Q

What does the position of progenitors dictate

A

position and type of differentiated neuron

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13
Q

How can neuronal character be understood?

A

Cartesian grid pattern

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