Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

BMS381 - Neurodevelopment > L3 & 4 - Hypothalamus Development > Flashcards

L3 & 4 - Hypothalamus Development Flashcards

1
Q

Layout of CNS neurons

A

columns and layers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Neuron layout in hypothalamus

A

neurons in clusters called nuclei

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Why is it hard to study hypothalamus

A

small, neurons intensely interlinked

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Effect of Shh deletion

A

hypothalamus does not develop

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Symptoms of Shh deletion

A

cyclopia, holoprosencephaly, no formation of ventral forebrain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

prechordal mesoderm function

A

expresses shh

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

prechordal mesoderm location

A

axial mesoderm underlying anterior neural tube

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Shh in hypothalamus

A

induces fan shaped set of cells in above neural plate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Technique of seeing shh effects

A

Ectopic transplant of pm expressing shh

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Examples of markers in hypothalamus

A

TFs - expressed in response to different conc of shh

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What happens to the arc patterns in the hypothalamus ?

A

rapidly obscured

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Specific examples of TF markers in hypothalamus

A

pax6
nkx2.2
foxa2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What structure generates arc pattern in hypothalamus?

A

prechordal mesoderm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

PM mechanism of action

A

changes signalling properties

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

PM signalling properties

A

first induces shh

then induces BMP & FGF10 expression in above neural cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Technique to detect FGF10

A

anti-sense in situ hybridisation

17
Q

Double in situ showed

A

population co-expresses shh, BMP7 & FGF & pathway components

18
Q

Why is co-expression of Shh, BMP & FGF unusual

A

TFs normally repress each others transcription

19
Q

Fate mapping of Shh, FGF10 & BMP7 positive cells showed

A

form hypothalamus

20
Q

Fate mapping technique

A

inject lipophilic dye DiL, double label expression of TF

21
Q

hypothalamic development model

A

sequential ansiotropic growth model

22
Q

What do FGF10, shh & BMP positive progenitors give rise to ?

A

anterior hypothalamic and posterior hypothalamic progenitors

23
Q

Movement of proliferating cells from FGF10, shh, BMP positive cells

A

anteriorly & posteriorly away - tangential movement

24
Q

what cells are retained?

A

central pool of FGF10+ positive progenitors

25
Q

Arc& VMN arose from ?

A

Shh responding progentiors

26
Q

TMN arose from ?

A

progenitors migrating in opposite direction ???? * CHECK

27
Q

FGF10+ population gives rise to ?

A

basal anterior & mammillary progenitors

28
Q

Progentiors patterned by shh –>

A

neurons that regulate sleep wake cycle

29
Q

FGF10+ hypothalamic cells

A

radial glial like cells - tanycytes

30
Q

beta tanycytes project to ?

A

median eminence

31
Q

alpha tanycytes

A

hypothalamic stem cells

32
Q

beta tanycyte function

A

allow metabolite & hormone entry into hypothalamus

33
Q

Tanycyte function - SC

A

neurogenesis - allostasis

allow body to adapt to new optimums

BMS381 - Neurodevelopment (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions