L10 - Neuronal Polarity Flashcards

1
Q

True or false - neurons have polarity

A

true

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2
Q

Dendrite function

A

integrate incoming information

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3
Q

Axon structure

A

highly polarised microtubules

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4
Q

Dendrite microtubules

A

less ordered, mixed orientations

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5
Q

MAPs (microtubule associated proteins) function

A

stabilise microtubules through cross-linking

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6
Q

Plasma membrane =

A

compartmentalised

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7
Q

Membrane compartments maintained by

A

actin dependent diffusion barriers

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8
Q

Axon microtubules

A

minus ends towards cell bodies

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9
Q

GFP labelled plus end directed kinesins mark

A

where axons try to form

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10
Q

neurite choice

A

stochastic, feedback loop , competition

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11
Q

Factors underlying axon choice

A

tyrosinated or acetylated microtubules ????

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12
Q

Acetylated microtubules

A

stabilised, present in newly polarised axons

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13
Q

Growth cones and neurite microtubules

A

tyrosinated dynamic microtubules

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14
Q

Activator function in positive feedback loop

A

amplifies signal

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15
Q

Likely feedback loop

A

HRas & PI3K positive loop

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16
Q

HRas depletion

A

non-axonal regions.

17
Q

Phosphorylated AKt location

A

nascent axons

18
Q

GSK3b inhibits

A

microtubule stabilisation

19
Q

Effect of inhibiting GSK3b

A

neurons with multiple axons

20
Q

Neuronal polarity affected by

A

proteins involved in asymmetric division EG Par

21
Q

PAr3 complex localisation

A

nascent growth cones

22
Q

PIP3 inhibition

A

prevents PAR3 accumulation and axon formation

23
Q

Balance between PAR related kinases promotes

A

axonogenesis

24
Q

Axon initiation in vivo requires

A

LKB1

25
Q

MAP2 marks

A

dendrites

26
Q

Tau marks

A

axons

27
Q

Semaphorins

A

inhibitory guidance cue family

28
Q

Sema3 expression

A

gradient from basal to apical

29
Q

Sema3 function

A

attracts dendrites basally, promotes dendrite formation

30
Q

Polarity can be inherited and established

A

true