L10 - Neuronal Polarity Flashcards by Isabella Smyth

Q

True or false - neurons have polarity

A

true

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Q

Dendrite function

A

integrate incoming information

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Q

Axon structure

A

highly polarised microtubules

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Q

Dendrite microtubules

A

less ordered, mixed orientations

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Q

MAPs (microtubule associated proteins) function

A

stabilise microtubules through cross-linking

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Q

Plasma membrane =

A

compartmentalised

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Q

Membrane compartments maintained by

A

actin dependent diffusion barriers

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Q

Axon microtubules

A

minus ends towards cell bodies

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Q

GFP labelled plus end directed kinesins mark

A

where axons try to form

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Q

neurite choice

A

stochastic, feedback loop , competition

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Q

Factors underlying axon choice

A

tyrosinated or acetylated microtubules ????

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Q

Acetylated microtubules

A

stabilised, present in newly polarised axons

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Q

Growth cones and neurite microtubules

A

tyrosinated dynamic microtubules

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Q

Activator function in positive feedback loop

A

amplifies signal

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Q

Likely feedback loop

A

HRas & PI3K positive loop

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Q

HRas depletion

A

non-axonal regions.

Q

Phosphorylated AKt location

A

nascent axons

Q

GSK3b inhibits

A

microtubule stabilisation

Q

Effect of inhibiting GSK3b

A

neurons with multiple axons

Q

Neuronal polarity affected by

A

proteins involved in asymmetric division EG Par

Q

PAr3 complex localisation

A

nascent growth cones

Q

PIP3 inhibition

A

prevents PAR3 accumulation and axon formation

Q

Balance between PAR related kinases promotes

A

axonogenesis

Q

Axon initiation in vivo requires

A

LKB1

Q

MAP2 marks

A

dendrites

Q

Tau marks

A

axons

Q

Semaphorins

A

inhibitory guidance cue family

Q

Sema3 expression

A

gradient from basal to apical

Q

Sema3 function

A

attracts dendrites basally, promotes dendrite formation

Q

Polarity can be inherited and established

A

true