L6 - Hypothalamic Energy Control Flashcards

1
Q

Experiment showed hypothalamus role in energy control

A

lesions in rodents

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2
Q

Lesion of VMN

A

hyperphagia

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3
Q

Aphagia

A

lack of eating

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4
Q

Lesions of lateral hypothalamus

A

aphagia

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5
Q

Adiposity signals

A

hormonal = insulin and leptin

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6
Q

Insulin & leptin act on?

A

arcuate nucleus

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7
Q

How do hormones reach the hypothalamus

A

through tanycytes

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8
Q

key neurons in Arcuate nucleus are

A

antagonistic

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9
Q

Neurons in Arcuate nucelus

A

NPY and POMC

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10
Q

NPY

A

neuropeptide

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11
Q

POMC

A

neurohormone

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12
Q

NPY function

A

stimulates food intake reduces energy expenditure

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13
Q

POMC function

A

reduce food intake

increase energy expenditure

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14
Q

POMC neuron release

A

a-melanocyte stimulating hormone

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15
Q

NPY inhibits

A

PVN

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16
Q

NPY stimulates

A

LHA

17
Q

PVN action

A

net catabolic

18
Q

LHA release

A

two neuropeptides
orexin A
melanin concentrating hormone

19
Q

ISLET1

A

key transcription factor

20
Q

ISLET1 function

A

determines identity of hypothalamic POMC neurons

21
Q

ISLET1 predicts

A

POMC expression

22
Q

ISLET1 predicts POMC - experiment

A

immunohistochemistry, transgenic reporter line

23
Q

ISLET1 homeobinding DNA motifs

A

nPE1

nPE2

24
Q

Model generated for ISLET1/POMC neuron

A

conditional KO mouse

25
Q

Key features of conditional KO mouse

A

cret2, tamoxifen, loxP, cre recombinase

26
Q

ISL1 KO model

A

POMC neurons fail to differentiate, early onset obesity

27
Q

Hypothalamic development model

A

sequential ansiotropic growth

28
Q

FGF10+ stem cell progenitors give rise to

A

ISLET1 progenitors

29
Q

type 2 diabetes

A

loss of neuron & function