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BMS381 - Neurodevelopment > L15 - Making maps I > Flashcards

L15 - Making maps I Flashcards

1
Q

Visual system mapping

A

topographic

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2
Q

Stripe assay shows

A

posterior tectum cells produced non-permissive factor that repels temporal retinal axons

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3
Q

Ephrin A2 and A5 KO’s

A

disordered topographic map

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4
Q

Axon elimination

A

electrical activity

competition

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5
Q

Electrical activity modulates

A

guidance cue response

Ca2+ and cAMP

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6
Q

Connection refinement

A

activity dependent

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7
Q

Hebbian rule

A

cells that fire together, wire together

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8
Q

Embryonic retina activation

A

spontaneous

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9
Q

Excitatory retinal waves

A

organised

reflects increases in intracellular calcium

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10
Q

Evidence that neural activity is required for topographic map refinement

A

sodium channel blocker and mice lacking nAChR

- lack map refinement

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11
Q

Neurotrophins

A

mediate electrical activity

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12
Q

BDNF

A

promotes RGC axon branching

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BMS381 - Neurodevelopment (15 decks)

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