L14 - Cues

Question 1

Intracellular cyclic nucleotide function

Answer 1

determine polarity of growth cone response to chemotropic molecules

Question 2

higher cAMP response

Answer 2

attractant

Question 3

manipulation of intracellular cyclic nucleotides

Answer 3

affects response to wide range of guidance cues

Question 4

Netrin response depends

Answer 4

cAMP signalling

Question 5

cAMP/cGMP ratios

Answer 5

critical factor for response

Question 6

Guidance responses alteration

Answer 6

by modulating cNMPs

Question 7

Molecules inhibiting CNS axon regeneration

Answer 7

Myelin associated glycoprotein

Nogo

Question 8

Effect of peripheral nerve lesion

Answer 8

facilitates CNS axon regeneration

Question 9

Inhibitory factors in CNS myelin converge on

Answer 9

RhoA pathway

Question 10

Db-cAMP function

Answer 10

promotes regrowth of central sensory afferents

Question 11

Db-aCMP recovery

Answer 11

functional = poor

Question 12

Rho-kinase (ROCK) inhibition

Answer 12

promotes corticospinal tract regrowth

Question 13

Ibuprofen

Answer 13

enhances DRG growth

inhibits RhoA activation

Question 14

Knockouts studies identified

Answer 14

PTEN

Question 15

PTEN function

Answer 15

regulates mTor pathway
enhances neuronal survival
regulates retinal axon regeneration

Question 16

PTEN deletion

Answer 16

enhances spinal axon regrowth