L5: Prostate Cancer Flashcards
Anatomical Overview of Prostate
Epidemeology of Prostate Cancer
Genitourinary Cancers
- % of solid tumors
Genitourinary Cancers
- Incidence of Mortality in each
RF for Prostate Cancer
RF for Prostate Cancer
- Non modifiable
Non Modifiable RF for Prostate Cancer
- Age
Non Modifiable RF for Prostate Cancer
- Race
Non Modifiable RF for Prostate Cancer
- Family Hx
Non Modifiable RF for Prostate Cancer
- Nationality
Non Modifiable RF for Prostate Cancer
- Genetics
Modifiable RF for Prostate Cancer
Precancerous Lesions in Prostate Cancer
Precancerous Lesions in Prostate Cancer
- PIN
Precancerous Lesions in Prostate Cancer
- PIA
Classification & Sites of Prostate Cancer
Classification & Sites of Prostate Cancer
- Epithelial Tumors
Classification & Sites of Prostate Cancer
- Stromal Tumors
Classification & Sites of Prostate Cancer
- Secondary Cause
Classification & Sites of Prostate Cancer
- Most Common Type
Microscopic Examination of Prostate Cancer
Microscopic Examination of Prostate Cancer
- Based On
Microscopic Examination of Prostate Cancer
- Gleason Grading System
Staging of Prostate Cancer
Staging of Prostate Cancer
- T
Staging of Prostate Cancer
- N
Staging of Prostate Cancer
- M
Spread of Prostate Cancer
Spread of Prostate Cancer
- Local
Spread of Prostate Cancer
- Lymphatic
Spread of Prostate Cancer
- Hematogenous
Spread of Prostate Cancer
- Most common Site of Hematogenous Mets
Dx of Prostate Cancer
Dx of Prostate Cancer
- CP
CP of Prostate Cancer
- Asymptomatic
CP of Prostate Cancer
- Manifest
CP of Prostate Cancer
- Complications
CP of Prostate Cancer
- Metastasis
Screening for Prostate Cancer
- Why?
- For Whom?
- How?
DRE in Prostate Cancer
Findings in DRE in Prostate Cancer
Size in DRE in Prostate Cancer
Accuracy of DRE in Prostate Cancer
False Positive in DRE in Prostate Cancer
False Negative in DRE in Prostate Cancer
INVx for Prostate Cancer
INVx for Prostate Cancer
- PSA
Def of PSA
Normal Values of PSA
levels of PSA Over Time
- Normal
- BPH
- Prostate Cancer
Factors increasing PSA
Factors Decreaseing PSA
Importance of PSA
Importance of PSA
- Diagnosis
Importance of PSA
- Staging & TTT Decision
Importance of PSA
- Follow Up
Follow Up by PSA
Follow Up by PSA
- Surgery
Follow Up by PSA
- radiotherapy
Follow Up by PSA
- Metastatic Cancer
Other Tumor Markers for Prostate Cancer
TRUS in Prostate Cancer
Value of TRUS in Prostate Cancer
False Positive in TRUS in Prostate Cancer
False Negative in TRUS in Prostate Cancer
Types of Tissue Biopsy in Prostate Cx
Indications of Tissue Biopsy in Prostate Cx
Indications of Tissue Biopsy in Prostate Cx
- Absolute
Indications of Tissue Biopsy in Prostate Cx
- Relative Indications
Interpretation of Age-Adjusted PSA
Def of PSA Velocity
Interpretation of PSA Velocity
Rationale of Free PSA
Interpretation of Free PSA
Rationale of PSA Density
Def of PSA Density
Interpertation of PSA Density
Imaging in Prostate Cx
Imaging in Prostate Cx
- CT, MRI
Indications of CT,MRI in Prostate Cx
Role of Pelvic Lymphadenectomy in Prostate Cx
Bone Scan in Prostate Cx
Indications of Bone Scan in Prostate Cx
Why is Bone Scan Mandatory in Prostate Cx?
Methods of Therapy in Organ-Confined Prostate Cx
Methods of Therapy in Prostate Cx
- T1a
Methods of Therapy in Prostate Cx
- T1b, T1c, T2
Methods of Therapy in Prostate Cx
- T3
Methods of Therapy in Prostate Cx
- Metastatic
Methods of Therapy in Prostate Cx
- Low Risk
Methods of Therapy in Prostate Cx
- Moderat Risk
Methods of Therapy in Prostate Cx
- High Risk
Methods of TTT of Prosate Cx
Methods of TTT of Prosate Cx
- Watchful Waiting
Methods of TTT of Prosate Cx
- Radical Prostatectomy
Methods of TTT of Prosate Cx
- Radiotherapy
Methods of TTT of Prosate Cx
- Depend on
Methods of Watchful Waiting in Prostate Cx
Indications of Watchful Waiting in Prostate Cx
CI of Watchful Waiting in Prostate Cx
Advantages of Watchful Waiting in Prostate Cx
Disadvantages of Watchful Waiting in Prostate Cx
Watchful Waiting in Prostate Cx
- NB
Indications of Radical Prostatectomy in Prostate Cx
CI of Radical Prostatectomy in Prostate Cx
Advanatages of Radical Prostatectomy in Prostate Cx
Disadvantages of Radical Prostatectomy in Prostate Cx
Method of External Radiation in prostate Cx
Indications of External Radiation in prostate Cx
CI in External Radiation in prostate Cx
Advanatges of External Radiation in prostate Cx
Disadvantages of External Radiation in prostate Cx
External Radiation in prostate Cx
- NB (Techniques)
Indications of Brachytherapy in Prostate Cx
CI of Brachytherapy in Prostate Cx
Advantages of Brachytherapy in Prostate Cx
Disadvantages of Brachytherapy in Prostate Cx
TTT options in Symptomatic Metastatic Disease
Indications of Hormonal TTT of Prostate Cx
Pathophysiology of Hormonal TTT of Prostate Cx
Lines of Hormonal TTT of Prostate Cx
Results of Androgen Removal in TTT of Prostate Cx
Medications used in Hormonal TTT of Prostate Cx
Hormonal TTT of Prostate Cx
- LHRH Analogues
Hormonal TTT of Prostate Cx
- Antiandrogenic
Finasteride & bicalutamide as primary hormonal therapy in advanced adenocarcinoma of the prostate
Significance of HRPC
TTT of HRPC
TTT of HRPC
- Cytotoxic Chemo
TTT of HRPC
- Bisphosphonate