L3: Hemangioma & AVM Flashcards
Incidence of Hemangioma
- The most common benign tumor of infancy
Sex in Hemangioma
Females are 3.5* in females
Pathophysiology of Hemangioma
Classification of Hemangioma
Incidence of Vascular Malformations
Less frequent
Sex in Vascular Malformations
Equal
Pathophysiology of Vascular Malformations
Classifications of Vascular Malformations
Classification of Hemangioma
- Supificial
Classification of Hemangioma
- Deep
Classification of Hemangioma
- Mixed
Classification of Vascular Malformations
- Slow Flow
Classification of Vascular Malformations
- Fast Flow
Classification of Vascular Malformations
- Complex Combined VMs
Natural History of Hemangioma
Natural History of Hemangioma
- Onset
- Not apparent at birth, appear around 2nd week of life. (with exceptions)
Natural History of Hemangioma
- Growth
Grow rapidly over next 6-10 months (Proliferating phase).
Natural History of Hemangioma
- Course
- Then a stationary course is followed by an involution phase (usually begins at 18 M.).
Natural History of Hemangioma
- Regression
Then regress slowly over next 7-10 years.
Natural History of Hemangioma
- Characters of Regression
Natural History of VMs
CP of Hemangioma
CP of Hemangioma
- During proliferating Phase
CP of Hemangioma
- During Involution Phase
CP of VMs
CP of VMs
- Capillary Malformations
CP of VMs
- Lymphatic Malformatioms
CP of VMs
- Venous Malformations
CP of VMs
- AVM
Complications of Hemangioma & VMs
Complications of Hemangioma & VMs
- KMS
- Some extensively large Hemangiomas may be complicated by coagulopathy & profound thrombocytopenia resulting from platelet trapping within the huge vascular lesion
Complications of Hemangioma & VMs
- HOHF
- This may occur withlarge Hemangiomas with intralesional arteriovenous shunting causing hyperdynamic circulation which increase the load on the heart.
Complications of Hemangioma & VMs
- Complications Related to Site
Peri-orbital: Interfere with visual axis, squint, amblyopia
Large cervical cystic hygromas: Airway obstruction
Dx of Hemangioma & VMs
Dx of Hemangioma & VMs
- Clinically
History & physicai examination may be sufficient for diagnosis.
Dx of Hemangioma & VMs
- Rad
- Ultrasonography & MRI are the principal useful imaging modalities.
- Doppler US characterize the flow of the vascular lesions (Hemangiomas & arteriovenous malformations are fast flow).
Dx of Hemangioma & VMs
- Doppler US
- Doppler US characterize the flow of the vascular lesions (Hemangiomas & arteriovenous malformations are fast flow).
Dx of Hemangioma & VMs
- Angiography
- Angiography indicate the extent of vascular involvement, show feeding & draining vessels, and can be used for selective embolization.
Management of Hemangioma
Management of Hemangioma
- Principals of TTT
Management of Hemangioma
- Observation
Management of Hemangioma
- Pharmacological TTT
- Propranolol
- CTS
Oral Proplanolol in Hemangioma
- Indications
- Now 1st line of treatment with excellent response, but with some precautions & possible side effects.
Oral Proplanolol in Hemangioma
- Dose
Oral Proplanolol in Hemangioma
- SE
Oral Proplanolol in Hemangioma
- CI
- Congenital heart disease
- Bronchial asthma
- Chronic obstructive pulmonary diseasee
Oral Proplanolol in Hemangioma
- response
- Near complete or complete regression ir 60%
Systemic Corticosteroids in Hemangioma
- Indication
- Especially in: Large, Rapidly growing, complicated lesions.
Systemic Corticosteroids in Hemangioma
- Dose
- 5g/kg/ day prednisone. for 6-8 weeks up to 12 W in severe cases.
- Gradually withdrawn over 3 W.
Systemic Corticosteroids in Hemangioma
- Complicatioons
- Facial oedema
- Truncal odesity
- Growth retardation
- Immunological abnormalities with recurrent infections
Systemic Corticosteroids in Hemangioma
- Response
Good response in third of cases.
LASER therapy in Hemangioma
Most appropriate for large flat lesions with significant cosmetic disfigurement.
Surgical Excison therapy in Hemangioma
- Best option for lesions in hidden areas.
TTT of Lymphatic Malformations
- Surgical excison
Surgical resection is the only method for potentiai cure, but:
- It is challenging because of the infiltrative nature of the lesion
- Followed by high incidence of recurrence because complete resection is difficult
- Possibly complicated by injury of important structures (trachea, oesophagus).
TTT of Lymphatic Malformations
- Aspiration?
Aspiration alone contraindicated
- It will be followed rapidly by cecollection
- It may be complicated byGemorrhage or infection with increases in size of the lesion.
TTT of Lymphatic Malformations
- Aspiration & Bleomycin Sclerotherapy
- Aspiration & Bleomycin sclerotherapy is a very effective therapeutic alternative.
TTT of Lymphatic Malformations
- Urgent tracheostomy
Urgent tracheostomy may be required in large cystic hygroma with airway obstruction.
TTT of Capillary Malformations
- LASER is the treatment of choice lesion.
TTT of Venous Malformations
- Intralesional sclerotherapy is the mainstay of treatmen:
(Injection of sclerosing agents as fibrin glue, ethanolamine) - Surgical resection reserved for well-localized lesions.
TTT of AVM
- The mainstay treatment: angiographic embolization alone or in combination with surgical
TTT of Choice
- Unnoticable Hemangioma
TTT of Choice
- Hemangioma
TTT of Choice
- Large, Rapid, Complicated Hemangioma
TTT of Choice
- Large, Flat Hemangioma
TTT of Choice
- hidden Hemangioma
TTT of Choice
- Cystic Hygroma
TTT of Choice
- Capillary malformations
TTT of Choice
- Venous Malformations
TTT of Choice
- AVM