L4, L6 Flashcards
sex is based on ___ expression, ___, ___ and ___
gene, anatomy, physiology, hormones
Gender and sex differences exist in the ___, ____, __ factors, ____ and ___ response for many psychopathologies
prevalence, symptomology, risk, course, treatment
Female biased disorders include late onset _____, eating disorders such as ___ and ____, ____ and mood disorders like ____ and ____
SZ, anorexia, bulimia, PTSD, depression, anxiety
male biased disorders include ___, ____, and learning disorders like ___, as well as ___, ___ and early onset ____
ADHD, autism, dyslexia, stuttering, tourettes, SZ
There are sex differences in pain ____, as well as how people ___ pain, how a physician may understand and ___ pain depending on their own gender
sensitivity, report, treat
Gender differences exist in vulnerabilities and _____ to the impact of ____ on mental well being. In general, ___ ___ individuals report poorer mental health
resistances, stress, gender diverse
There is a false narrative that ___ ____ _____ influence facts and evidence as well as beliefs. It is misunderstood that these differences will lead to ___, ____ data.
ovarian hormone fluctuations, complicated, uninterpretable
looking at the physiology, receptors, and learning in animals found that the ___ __ ____ in males was actually greater on average than in females. Moreover, variability of behaviour, ___, ____, neurochemistry, and non brain measures found that there was non significant across ___, ___ and ___ cycles. There was no difference in variability within gender groups among different rat ___ as well
coefficient of variability, histology, electrophysiology, estrus, diestrus, proestrus, strains
Moreover, testosterone changes through the ___ and the ___ in both humans and rats. This occurs regardless of ___ ____. In rats, T increases in the ____ period and decreases in the ___ period
day, lifetime, food restriction, light, dark
Many research papers do not include ___ __ _ ___ ___, and will incorrectly determine the male brain to be the _____, and only consider females if some effect is not seen in males first
sex as a biological variable, default
when an endpoint has two distinctive forms, with one almost exclusively present in one sex vs the other
sex dimorphism
when the endpoint les along a continuum with different averages for males vs females, but much overlap
sex difference
when neural and hormonal factors act to make endpoint in males and females more similar or opposing
sex convergence / divergence
when the endpoint is the same in males vs females, but the frequency with which it occurs differs
population differences
In males, the ___ gene promotes the ___ ___ ___ that leads to testes development. The ___ gene also pushes testes development.
SRY, testes determining factor, Sox9
In females, the _____ on the ___ chromosome, will turn off the ___ gene to produce female characteristics. Moreover, turning off the TDF and sox9 does not necessarily produce fully female or male characteristics, showing that sexual differentiation in females is not ___ or the ____
beta-catenin, third, Sox9, passive, default
A series of events whereby a sexually indifferent embryo progressively acquires male or female characteristics
sexual differentiation
early embryonic life when no sex differences have developed
bipotential stage
in the bipotential stage, which is the first ___ weeks in humans, the ___ are identical and both ___ and ____ ducts are present
6, gonads, mullerian, wolffian
Sexual differentiation begins with the ___ ___ differentiating into either the ____ or ____. These drive sexual differentiation in the morphology of the ____
genital ridge, testes, ovaries, genitals
In males, the __ ____ _____ regresses the ___ duct, and presence of ____ ____ and further develops the wolffian duct. Then _____ converts testosterone to ____, which elongates the genital tubercle to become the penis
mullerian inhibiting hormone, mullerian, testosterone, stabilizes, 5-alpha-reductase, dihydrotestosterone
in females, there is no ____ hormone product by the ovaries. This causes the ____ ___ to destabilize and ____, while the mullerian duct continues to develop. ___ ___ such as ____ also suppress genes that would lead to male development and continue mullerian duct development. Then the absence of testosterone and _____ leads to the development of the clitoris from the genital tubercle
perinatal, wolffian duct, degenerate, transcription factors, COUP-TFIII, DHT
the ___ ___ is the bipotential precursor of the penis and clitoris and is homologous and _____ in XX and XY individuals in early development. It becomes recognizably different __ weeks of gestation in humans
genital tubercle, indistinguishable, 9
when testicular androgens and hormones drive the development of male-typical reproductive physiology and behaviour
masculinization