L39 Corticospinal and Corticobulbar Fibers Flashcards

1
Q

what cortex does motor planning?

A

prefrontal and limbic cortex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what cortex does production of motor programs?

A

premotor cortex (BA 6)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what cortex executes motor activity?

A

primary motor cortex (BA 4)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what do the premotor cortex pyramidal layer 5 cells that project via? what does it do?

A

corticospinal tract

excite motor neurons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what does the medial aspect of the premotor cortex contain?

A

the supplemental motor area

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what do the layer 5 pyramidal cells of the primary motor cortex make excitatory synapses to?

A

LMN’s in the spinal cord both directly and indirectly via interneurons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what has a distinct somatotropic map?

A

primary motor cortex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

where does the motor cortex receive input from?

A
  • primary somatosensory (BA 3,1,2)
  • post. parietal areas (BA 5,7) = integrates sensory info for motor planning
  • basal ganglia (via thalamus and premotor area)
  • cerebellum (via thalamus)
  • visual center
  • auditory center
  • limbic and prefrontal areas
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

where does the premotor cortex receive input from?

A
  • post. parietal area
  • basal ganglia (via thalamus)
  • cerebellum (via thalamus)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what does simple finger movement activate?

A
  • motor cortex

- somatosensory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what does complex finger movements activate?

A
  • premotor cortex

- supplemental motor cortex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what does rehearsed finger movements activate?

A

-supplemental cortex (programmed from rehearsal)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what is the predominant role of the lateral corticospinal tract?

A

voluntary contraction of distal flexor muscles of the limbs - reaching and walking

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

sensory input from the lateral corticospinal tract is constantly processed by the ____ and modified by the ___ and ____

A

cortex
BG
cerebellum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

where does the corticospinal tract start?

A

pyramidal cells layer 5 of preCG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

where does the corticospinal tract end?

A

contralateral anterior horn (gray matter) of the spinal cord where the UMN synapse on alpha-gamma LMNs

17
Q

what is the route of the corticospinal tract?

A
  • corona radiata
  • internal capsule
  • crus cerebri
  • basilar pons
  • pyramid (medulla)
  • pyramidal decussation (causal medulla)
  • (lateral) corticospinal tracts in spinal cord
  • alpha/gamma LMNs
18
Q

what do LMN lesions result in?

A
  • paralysis/paresis
  • areflexia/hyporeflexia
  • atrophy/wasting
  • faciculations due to denervation which show on EMG as fibrillations
19
Q

what side, in relation to the damage, do LMN symptoms occur?

A

ipsilateral (same)

20
Q

what are examples of LMN syndromes?

A
  • ALS (Lou Gehrig’s disease)

- peripheral nerve damage (traumatic)

21
Q

what do UMN lesions result in?

A

initially - flaccifity and arefleia due to spinal shock
after weeks - spinal cord circuits regain function and motor sx/sx emerge to include
-spastic paralysis (increase muscle tone)
-postitive babinski reflex
-hyperreflexia

22
Q

in UMN lesions, above the lesion which side is affected?

A

contralateral to side of lesion

23
Q

in UMN lesions, below the lesion, which side is affected?

A

ipsilateral to side of lesion

24
Q

what are the symptoms of paraplegia?

A
  • flaccid paralysis below lesion (spinal shock) then spasticity
  • increase deep tendon reflex and clonus
  • +Babinski reflex
  • urine retention,
  • painless bladder distension + overflow
  • decrease flexor spasms
  • loss of all somatosensory below
25
Q

the lateral corticospinal and corticobulbar tracts are the most important motor pathways that arise in the primary motor cortex and overlap with what?

A
  • precentral gyrus (lateral)

- anterior paracentral lobule (medial)

26
Q

how do the thalamus permit regulation of the motor cortex?

A

by BG and cerebellum

*BG and cerebellum does not control LMN, they talk to motor centers, so they can INDIRECTLY regulate LMN

27
Q

what is the medial premotor (supplementary) area involved in?

A

planned sequences

28
Q

what is the lateral premotor areas involved in?

A

sensory-guided movements

29
Q

axons forming these two are the same - if you damage one, you will get degenerations of the other.

A

crus cerebri

pyramids

30
Q

the continuous axons from crus cerebri to pyramid are not visible on the ventral surface of the pons, given the presence of _____ which form the middle
cerebellar peduncles.

A

superficial transverse pontine fibers

31
Q

which part of the internal capsule do the corticospinal and corticobulbar fibers run?

A

posterior limb of internal capsule

32
Q

A minority of corticospinal fibers (typically arising from parietal areas) will
terminate in the _____ presumably to regulate sensory inputs.

A

dorsal spinal gray matter

33
Q

The upper motor neurons
commonly release glutamate onto
AMPA receptors, either directly or
indirectly activating ______

A

alpha / gamma LMN

34
Q

when does paraplegia occur?

A

after spinal cord injury