L31 Pregnancy, Parturition and Lactation Flashcards

1
Q

What is fertilisation?

A
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2
Q

Where are gametes transported to during fertilisation?

A

Gametes transported to ampulla of oviduct

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3
Q

What cells surround the oocytes?

A

They are surrounded by granulosa cells

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4
Q

What mechanisms allow the 50-100 ampulla make successful penetration?

A
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5
Q

What is sperm acrosomal reaction?

A

Penetration

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6
Q

What happens during the Oocyte ‘activation’ cortical reaction?

A

Calcium increase:
- Second meiotic division
- Prevents polyploidy

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7
Q

What is polyploidy?

A
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8
Q

What is Pre-implantation?

A
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9
Q

Describe the process of pre-implantation

A
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10
Q
A

Conceptus nourished by oviduct secretions - 3 days

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11
Q
A

Fluid filled cavity lined by trophoectoderm layer —> yolk sac, foetal placenta and amnion

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12
Q

What is a blastocyst and how does it form?

A
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13
Q

What happens during the cleavage stage of the preimplantation phase?

A
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14
Q

What is implantation?

A
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15
Q

When does implantation often occur?

A

6-10 days after ovulation

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16
Q

Why is the low oestradiol to progesterone ratio important?

A
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17
Q

What is the oestradiol to progesterone ratio like in the endometrium reception of blastocyst?

A
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18
Q

What does the Blastocyst promote during implantation?

A

It promotes endometrial stromal cells - predecidualisation —> decidua

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19
Q

What are the two blastocyst trophoblastic cells?

A
  • Inner cytotrophoblast
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20
Q

What are the 4 stages of endometrial invasion?

A
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21
Q

How does the zona pellucida disintegrate?

A

Lytic factors break down the zona pellucida

22
Q

What does the embryonic pole do?

A
23
Q

What happens during hatching in the endometrial invasion?

A
24
Q

What happens during apposition in endometrial invasion?

A
25
Q

What happens during adhesion in the endometrial invasion?

A
26
Q

What happens during invasion in endometrial invasion?

A

Trophoblastic cell proliferation + differentiation to syncytial

27
Q

What is the main role of the placental development?

A

Acts as a life support system - around 120 maternal spiral arteries that bring pulsate blood

28
Q

What adaptations does the placenta have to support the baby for 9 months?

A
  • Intervillous spaces reduces force + velocity for exchange
  • Syncytiotrophoblast lacunae - merge + fill with maternal blood
29
Q

How does the villi/microvilli projecting into the maternal blood form?

A

Cytotrophoblasts and syncriotrophoblasts form it

30
Q

Foetal + maternal blood in the mature placenta is separated by what 4 things?

A
  • Foetal capillary endothelium
  • Mesenchyme
  • Cytotrophoblast
  • Syncytiotrophoblast
31
Q

How are maternal and foetal blood different?

A
32
Q

What substances are transported from the maternal blood to the foetal blood?

A

-

33
Q

What substances are transported from the foetal blood to the maternal blood?

A
34
Q

Why does the foetal haemoglobin have a higher affinity compared to the maternal haemoglobin?

A

Competitive for the same oxygen (finish)

35
Q

How are large molecules transported between the foetal and maternal blood?

A
36
Q

What is HCG?

A
37
Q

What is the result of HCG rescuing corpus luteum?

A

Continues secretion oestrogen and progesterone to support endometrium

38
Q
A

1) Coordinate fuel economy
2) Development mammary glands

39
Q

What is Quiescence?

A
40
Q
A

Is Quiescence 95% of the gestation period?

41
Q
A
  • Uterus relaxed and insensitive to uterotonic hormones
  • Progesterone suppresses myometrial contractions
42
Q

What are the stages of Parturition?

A
43
Q

What does Prostaglandin do during activation/ transformation?

A
  • Promotes formation of gap junctions
  • Softening, thinning + dilation of cervix
44
Q

What 3 things are increased during birth?

A
45
Q

What is the positive feedback during the 2nd stage of parturition ?

A
46
Q

What are the 3 stages of labour and delivery?

A
  1. Dilation (placental relaxin)
  2. Expulsion
  3. Placental (separation from decidua)
47
Q

What is the 3rd stage of parturition ?

A
48
Q

What happens to placental oestrogen and its stimulation?

A
49
Q

How long does the endometrial cycle take?

A

3-5 months

50
Q

What are the secretory units of the breast?

A
51
Q

What are the effects of production of oestrogen during pregnancy for lactation?

A