L17 Gene Models And Nephron Function 1

Question 2

What is the first step of the production of urine?

Answer 2

Glomerular filtration reminder

Question 3

List the parts of nephron, in the correct order

Answer 3

1. Glomerulus
2. PCT - Proximal convoluted tubule.
3. loop of henle
4. Distal convoluted tubule
5. Collecting duct.

Question 4

What is Bowman’s capsule?

Question 5

What is the standard glomerular filtration rate (GFR)?

Answer 5

125 ml/min

Question 6

What is in the renal tubule?

Answer 6

Proximal tubule, loop of henle, distal tubule and collecting duct

Question 7

Describe the direction of transcellular reabsorption

Answer 7

Goes from lumen or tubule, across the tubular epithelium and into the peritubular capillary

Question 8

What’s the difference between paracellular and transcellular secretion/ reabsorption?

Answer 8

Paracellular secretion happens in between the cells and not across the cells like transcellullar

Question 9

What’s the direction of transcellular secretion ?

Question 10

What % of filtrate, H2O and sodium ions, glucose + amino acids and HCO3- that are filtered are absorbed?

Question 11

Which side is the filtrate on? (Finish)

Answer 11

Apical side

Answer 12

Different transport proteins allow net transport

Question 13

How does a potassium concentration gradient establish within the proximal tubule epithelium?

Answer 13

Sodium, potassium pump and then the potassium pump

Question 14

Why is it important that sodium ions are actively transported out of the proximal tubule?

Answer 14

Symport of the 3 different sodium ions

Answer 15

NAPE2A (sodium + phosphate) transport. Net absoprtion or sodium and phosphate. Uses sodium gradient

Answer 16

Water reabsorption in proximal tubule

Question 17

What happens if we lose the NAPE2A transporter?

Answer 17

Urinating phosphate

Question 18

What happens if there’s more Pi tubular fluid?

Question 19

What does the carbonic anhydrase do?