L30 Fungi Flashcards by Jason Tepper

Cell walls made of

chitin
mannan
glucan

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Fungi oxygen

Strict aerobes

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Bakers yeast

facultative anaerobe

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Fungus structural differences

septate hyphae

aseptate hyphae

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Mycelium

hyphal mass

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Septate

hyphae with cross walls

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Coenocytic

hyphate w/o cross walls

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Yeast to mold or mold to yeast?

Most go mold to yeast except candida

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Required to eliminate fungal infection

T-cell mediated immunity

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Endemic

Histoplasma capsulatium Temp
blastomyces dermatitidis Temp
coccidiodes immitis, posadasi Non-Temp

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Histo transformation

temperature

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H. capsulatum type of infection

Reticuloendothelial system infection

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Blastomyces appearance

Broad based buds

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Coccidiodes entry

Transform into spherules filled with endospores

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Coccidiodes Temp dependence

NOOOOOOOOOO

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C. immitis disease

Desert rheumatism or Valley fever

C. immitis spread and multiplication

Disseminated coccidiodiomycosis–>chronic meningitis

Disseminated coccidiodiomycosis complication

Chronic meningits

Disseminated coccidiodiomycosis treatment

Itraconazole: interferes wtih ergosterol synthesis

Opportunistic fungi

Candida
Cryptococcus neoformans, gattii
Aspergillus
Mucormycetes
Pneumocystis jiroveci

Candida found in this form

mycelial, found in tissue

Diaper rash caused by

intertriginous candidiasis

Aspergillus significance

Ubiquitous

Aspergillus species

A. fumigatus

A. flavus

Aspergillus on normal tissue

Only in profoundly immunocompromisedindividuals

Mucormycosis forms

Rhinocerebral: diabetics | Disseminated

Seborrheic dermatitis:

Subcutaneous | patches of greasy scales

Tinea versicolor

hyperpigmented skin | superficial mycoses

Antifungals

Capsofungin | Micafungin

Capsofungin | Micafungin are types of

Echinocandins