L25 Hepatitis viruses Flashcards
Hep A
Family
Genome
Virion
Picornaviridae
(+)ssRNA
Nonenveloped
Hep B
Family
Genome
Virion
Hepadnaviridae
Circular dsDNA
Enveloped
Hep C
Family
Genome
Virion
Flaviviridae
(+)ssRNA
Enveloped
Hep A transmission
Fecal-oral
Sexual
Parenteral
Hep B transmission
Sexual
Vertical
Parenteral
Hep C transmission
Sexual
Vertical
Parental
Hep A incubation
15-40 days
Hep B incubation
60-180 Days
Hep C incubation
60-120 days
Hep B symptoms
malaise
Jaundice: elevated ALT levels
anorexia
vomiting, fatigue, cough
Hep B recovery time
3-4 months after jaundice
Chronic Hep B
What to look for
Empty particles
Sporadic episodes of haptitis
Chronic hep B
Risks
Hepatocellular carcinoma (HCC)
Hep B vaccination
Multiple inoculations
No effective against chronic
Chronic: interferon, nucleoside analogs
Hep C compared to Heb B
milder symptoms
Chronic much more common