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Micro 2 > L26 Retroviruses > Flashcards

L26 Retroviruses Flashcards

1
Q

Retrovirus 4H club

A

Homosexual men
Heroin addicts
Haitians
Hemophiliacs

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2
Q

HIV theory

A

SIV–>HIV-2(hetero)–>HIV-1(homo)

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3
Q

Retrovirus families

A

Orthoretroviridae

Spumaviridae

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4
Q

Retrovirus
Genome
Virion

A

(+)ssRNA diploid, identical copies

Enveloped

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5
Q

Retrovirus proteins

A

Revers transcriptase
Integrase
Protease

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6
Q

Simple retroviruses encode these genes

A

Gag
Pro
Pol
Env

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7
Q

Replication cycle

A 
ssRNA-->dsDNA
Integration of virus dsDNA making provirus
Transcription
Translation
Assembly 
Release
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8
Q

What is needed for reverse transcription?

A

High levels of NTP

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9
Q

Retroviruses are silent when

A

identical

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10
Q

Reverse transcription occurs in

A

in cytoplasm

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11
Q

Integration occurs in _____ during ______

A

nucleus during mitosis

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12
Q

Integration identified oncogenes

A

Transcription factors
Secreted growth factors
Growth factor receptors
Cell Signal transduction pathways

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13
Q

Slow retroviruses result in

A

high level mutagenesis

eventual tumorigenesis

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14
Q

cytopathic retroviruses
Prevalence
Cause

A

Minority of retroviruses

Cause direct tissue damage

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15
Q

Acute transforming viruses

Result in

A

Rapid tumor formation

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16
Q

HTLV-1 transmission

A

Person to person

17
Q

HTLV-1 spread within host

A

highly cell associated

18
Q

HTLV-1 disease

A

Adult T-cell lymphoma/leukemia

HTLV-1 Associated Myelopathy/Tropical Spastic Parapesis (HAM/TSP)

19
Q

Adult T-cell lymphoma/leukemia latent period

A

30-50 years

20
Q

HTLV-1 infects

A

memory T-cells

21
Q

HAM/TSP latency period

A

3 years

22
Q

HAM/TSP symptoms

A

Bladder control
lower back pain, leg weakness, stiff hips
Men: ED

23
Q

ATLL treatment

A

chemotherapy

24
Q

HAM/TSP treatment

A

Corticosteroids

Interferon

25
Q

HIV is highest in

A

Sub-saharan africa

26
Q

AIDS Latent period

A

6 months - 25 years

27
Q

HIV Target

A

CD4+ cells

Micro 2 (11 decks)

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