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Micro 2 > L29 Herpes > Flashcards

L29 Herpes Flashcards

1
Q

Herpes Simplex Virus
Family
Genome
Virion

A

Alphaherpesviridae
dsDNA
Enveloped

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2
Q

Herpes reproduction cycle length

A

Short

Rapid spread in culture

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3
Q

Herpes host range

A

variable

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4
Q

Herpes latency location

A

Capacity to establish latency in sensory ganglia

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5
Q

Herpes 1 vs 2

A

1: eyes, oral
2: genital

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6
Q

HSV-1 transmission

A

oral oral

oral genital

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7
Q

HSV 2 transmission

A

genital genital

oral genital

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8
Q

HSV incidence

A

1: 2/3
2: 1/5

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9
Q

HSV incubation period

A

2-14 days (4-5 usually)

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10
Q

HSV symptoms

What percentage show

A

flu like symptoms w/ lesions

only 1/3 show symptoms

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11
Q

Latency

A

Genome circularizes and stays as an episome

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12
Q

Herpes outbreak tiggers

A

sunburn
systemic infection
immune impairment
stress

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13
Q

What type of immune response is required for herpes?

A

Cell mediated

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14
Q

What happens when someone is unable to produce antibodies?

A

They can still handle herpes

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15
Q

How does herpes modulate immune response

A

Bind antibodies

Conter the effects of interferon

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16
Q

Herpes treatment

A

acyclovir

Wont eliminate latent infection

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17
Q

Cytomegalovirus
Family
Genome
Virion

A

Betaherpesvirus
dsDNA
Enveloped

18
Q

CMV host range

A

restricted

19
Q

Cmv reproductive cycle

A

Long

slow progression in cell culture

20
Q

Epstein-Barr virus
Family
Genome
Virion

A

Gammaherpesvirus
dsDNA
nonenveloped

21
Q

Epstein barr targets

A

T and B lymphocytes

22
Q

CMV type of infection

A

Chronic persistant infection, not latent

23
Q

CMV infected cells

A

Become enlarged

24
Q

Epstein barr type of infection

A

lytic

25
Q

Epstein barr latency in

A

lymphoid tissues

26
Q

CMV exposure routes

A

Saliva
Urine
Sex

27
Q

EBV exposure

A

Saliva

28
Q

Clinical manifestatio of EBV, CMV in young adults

A

Mono

29
Q

EBV carcinoma

A

Burketts lymphoma

Hodgkins lymphoma

30
Q

Burketts lymphoma

A

tumor in jaw, eye socket, ovaries

common in equitorial africa

31
Q

Types of hodgkins lymphoma

A

Nodular scLerosiing
Mixed Cellularity
Lymphocyte Depleted

32
Q

Key characteristic of Beta/gammaherpesvirus

A

Immune evasion by inhibiting apoptosis and immune response

33
Q

Antiviral therapy recommended for

A

disseminated CMV, EBV

34
Q

CMV, EBV treatment

A

antiviral
Immunoprophlaxis
No vaccines

35
Q

HPV
Family
Genome
Virion

A

Papillomaviridae
Circular dsDNA
non envelope icosahedral

36
Q

HPV infection in ____ layer of skin

A

basal

37
Q

_____ required for hpv genome repliation

A

cell polymerase

38
Q

Is HPV lytic or non lytic

A

non lytic

39
Q

HPV spreads thru

A

skin to skin

fomites

40
Q

HPV complication

A

Respiratory papillomatosis

41
Q

HPV cancer

A

E7 blocks RB: cell proliferation

E6 blocks p53 tumor suppressor pathway

42
Q

How do condoms reduce risk of hpv

A

no proof that they actually do reduce risk

Micro 2 (11 decks)

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