L29 Herpes

Question 1

Herpes Simplex Virus
Family
Genome
Virion

Answer 1

Alphaherpesviridae
dsDNA
Enveloped

Question 2

Herpes reproduction cycle length

Answer 2

Short

Rapid spread in culture

Question 3

Herpes host range

Answer 3

variable

Question 4

Herpes latency location

Answer 4

Capacity to establish latency in sensory ganglia

Question 5

Herpes 1 vs 2

Answer 5

1: eyes, oral
2: genital

Question 6

HSV-1 transmission

Answer 6

oral oral

oral genital

Question 7

HSV 2 transmission

Answer 7

genital genital

oral genital

Question 8

HSV incidence

Answer 8

1: 2/3
2: 1/5

Question 9

HSV incubation period

Answer 9

2-14 days (4-5 usually)

Question 10

HSV symptoms

What percentage show

Answer 10

flu like symptoms w/ lesions

only 1/3 show symptoms

Question 11

Latency

Answer 11

Genome circularizes and stays as an episome

Question 12

Herpes outbreak tiggers

Answer 12

sunburn
systemic infection
immune impairment
stress

Question 13

What type of immune response is required for herpes?

Answer 13

Cell mediated

Question 14

What happens when someone is unable to produce antibodies?

Answer 14

They can still handle herpes

Question 15

How does herpes modulate immune response

Answer 15

Bind antibodies

Conter the effects of interferon

Question 16

Herpes treatment

Answer 16

acyclovir

Wont eliminate latent infection

Question 17

Cytomegalovirus
Family
Genome
Virion

Answer 17

Betaherpesvirus
dsDNA
Enveloped

Question 18

CMV host range

Answer 18

restricted

Question 19

Cmv reproductive cycle

Answer 19

Long

slow progression in cell culture

Question 20

Epstein-Barr virus
Family
Genome
Virion

Answer 20

Gammaherpesvirus
dsDNA
nonenveloped

Question 21

Epstein barr targets

Answer 21

T and B lymphocytes

Question 22

CMV type of infection

Answer 22

Chronic persistant infection, not latent

Question 23

CMV infected cells

Answer 23

Become enlarged

Question 24

Epstein barr type of infection

Answer 24

lytic

Question 25

Epstein barr latency in

Answer 25

lymphoid tissues

Question 26

CMV exposure routes

Answer 26

Saliva Urine Sex

Question 27

EBV exposure

Answer 27

Saliva

Question 28

Clinical manifestatio of EBV, CMV in young adults

Answer 28

Mono

Question 29

EBV carcinoma

Answer 29

Burketts lymphoma | Hodgkins lymphoma

Question 30

Burketts lymphoma

Answer 30

tumor in jaw, eye socket, ovaries | common in equitorial africa

Question 31

Types of hodgkins lymphoma

Answer 31

Nodular scLerosiing Mixed Cellularity Lymphocyte Depleted

Question 32

Key characteristic of Beta/gammaherpesvirus

Answer 32

Immune evasion by inhibiting apoptosis and immune response

Question 33

Antiviral therapy recommended for

Answer 33

disseminated CMV, EBV

Question 34

CMV, EBV treatment

Answer 34

antiviral Immunoprophlaxis No vaccines

Question 35

HPV Family Genome Virion

Answer 35

Papillomaviridae Circular dsDNA non envelope icosahedral

Question 36

HPV infection in ____ layer of skin

Answer 36

basal

Question 37

_____ required for hpv genome repliation

Answer 37

cell polymerase

Question 38

Is HPV lytic or non lytic

Answer 38

non lytic

Question 39

HPV spreads thru

Answer 39

skin to skin | fomites

Question 40

HPV complication

Answer 40

Respiratory papillomatosis

Question 41

HPV cancer

Answer 41

E7 blocks RB: cell proliferation | E6 blocks p53 tumor suppressor pathway

Question 42

How do condoms reduce risk of hpv

Answer 42

no proof that they actually do reduce risk