L27 Neuroviruses Flashcards
Eastern Equine encephalitis Venezuelan equine encephalitis Family Genome Virion
Togaviridae
(+)ssRNA
Enveloped
EEE and VEE require
Endoplasmic reticulum
EEE, VEE introduced by
bite of infected arthropod
Path to blood stream
Langerhans–>lymph node–> blood or
Muscle–>blood
Eastern Equine encephalitis
Incubation period
4-10 days
Eastern Equine encephalitis
systemic symptoms
chills,fever, malaise, myalgia 1-2 weeks
Eastern Equine encephalitis
Encephalitic disease
Fever, headahe, vomit, diarrhea, convulsion, coma
Eastern Equine encephalitis
Encaphalitc disesase death
1/3 die within 2-10 days
EEE and VEE
Treatment
Vaccine live attenuated TC83
No Treatment
EEE vector
Culiseta melanura (excusively feed on birds in freshwater hardwood swamps)
West Nile Virus
Incubation time
2-14 days
West Nile Virus
Symptoms
Most people are asymptomatic
West Nile Virus treatment
No treatment
No vaccine
West Nile mosquitos
Culex sp.
Zika virus
Family
Genome
Virion, shape
Flaviviridae
(+)ssRNA
Enveloped, spherical
Zika virus host
life long infection in mosquitos
Zika virus disease
Zika fever
Zika fever symptoms
fever
red eyes
joint pain
rash
Zika virus transmission
Mosquitos (aedes)
sex
blood transfusion
vertical
Zika virus complications
Guillain barre syndrom
Newborn microcephaly
Why are WNV and EEE so different?
Because of their vectors..West nile is all over US
Rabies
Family
Genome
Virion
Rhabdoviridae
(-)ssRNA
enveloped
Rabies virus protein
L-polymerase
Rabies incubation period
1-3 months
