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Micro 2 > L24 Childhood viruses > Flashcards

L24 Childhood viruses Flashcards

1
Q

Measles virus
Family
Genome
Virion

A

Paramyxovirus
(-)ssRNA
Enveloped

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2
Q

Measles replication

A

Inside cell, NOT NUCLEUS

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3
Q

Measles appearance under microscope

A

Syncytia formation

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4
Q

Measle incubation period

Days (fast or slow)

A

10-14 days

Fast

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5
Q

Measles significance

A

Most deadly of Childhood rash/fever ilnesses

One of the most contagious diseases known

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6
Q

Measles infection spread

A

Epithelial tissues–>second round replication in LN, etc–>symptoms

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7
Q

Measles symptoms

A

Koplik spots*
2-3 day fever
cough
conjunctivitis

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8
Q

Measles complications

A

Blindness in Vit A deficient children
ADEM: demyelinating disease
SSPE: 7-10 after infection, neuro deterioration

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9
Q

Measles lab detection

A

ELISA

RT-PCR

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10
Q

Measles hosts

A

Humans

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11
Q

Measles treatment

A

No antivirals
Vitamin A reduces severity
Vaccine is best option

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12
Q

Respiratory Syncytial Virus
Family
Genome
Virion

A

Paramyxovirus
(-)ssRNA
Enveloped

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13
Q

Respiratory Syncytial Virus infects these cells

A

ciliated cells of respiratory epithelium

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14
Q

Respiratory Syncytial Virus significance

A

Most important viral agent for pediatric respiratory infections

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15
Q

Respiratory Syncytial Virus replication

A

limited to respiratory tract

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16
Q

Respiratory Syncytial Virus incubation period

A

4-5 days

17
Q

Respiratory Syncytial Virus immunity

A

Not life long b/c slow immune response

18
Q

Respiratory Syncytial Virus prevention

A

No antivirals
No faccine
Passive immunoprohlaxis (humanized antibody)

19
Q

Varicellla zoster virus
Family
Genome
Virion

A

Alphaherpesvirus
dsDNA
Enveloped

20
Q

Varicellla zoster virus disease

A

chickenpox

21
Q

Varicellla zoster virus proteins

A

Hundreds of proteins

22
Q

Varicellla zoster virus

Replication

A

Needs active cell

23
Q

Varicellla zoster virus

Infection

A

inhalation of aerosolized droplets

24
Q

Varicella zoster Incubation period

A

10-21 days

25
Q

Chickenpox vs small pox

A

Chicken: Trunk and face
small: arms and legs

26
Q

Chickenpox prevention

A

Vaccination: life long immunity
Antivirals: cannot eliminate latent virus

27
Q

Poliovirus replication

A

In cell
Creates pore in cell membrane
Primary replicaiton in peyers of Small I. not bad
Secondary: major viremia, gray matter replication

28
Q

Polio complications

A

CNS involvement
Replication in gray matter of brain and spinal cord
Limb paralysis from anterior horn
Respiratory paralysis from medulla oblongata

29
Q

Polio Vaccination

A

Salk: killed
Sabin: live attenuated

30
Q

Polio reservoirs

A

Only humans

31
Q

Rotavirus
Family
Genome
Virion

A

Reoviridae
dsRNA: 11 segments
Non enveloped

32
Q

Rotavirus replication

A

In cell

Receptor mediated endocytosis

33
Q

Rotavirus unique feature

A

Genome never exposed

34
Q

Rotavirus incubation period

A

2 days

35
Q

Rotavirus symptoms

A

Vomiting and fever for 2 days

Diarrhea for another 3-8

36
Q

Rotavirus diagnosis

A

antigens in stool

37
Q

Rotavirus prevention

A

Infant vaccines
No antivirals
Hygiene
Oral rehydration

Micro 2 (11 decks)

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