L24 Childhood viruses

Question 1

Measles virus
Family
Genome
Virion

Answer 1

Paramyxovirus
(-)ssRNA
Enveloped

Question 2

Measles replication

Answer 2

Inside cell, NOT NUCLEUS

Question 3

Measles appearance under microscope

Answer 3

Syncytia formation

Question 4

Measle incubation period

Days (fast or slow)

Answer 4

10-14 days

Fast

Question 5

Measles significance

Answer 5

Most deadly of Childhood rash/fever ilnesses

One of the most contagious diseases known

Question 6

Measles infection spread

Answer 6

Epithelial tissues–>second round replication in LN, etc–>symptoms

Question 7

Measles symptoms

Answer 7

Koplik spots*
2-3 day fever
cough
conjunctivitis

Question 8

Measles complications

Answer 8

Blindness in Vit A deficient children
ADEM: demyelinating disease
SSPE: 7-10 after infection, neuro deterioration

Question 9

Measles lab detection

Answer 9

ELISA

RT-PCR

Question 10

Measles hosts

Answer 10

Humans

Question 11

Measles treatment

Answer 11

No antivirals
Vitamin A reduces severity
Vaccine is best option

Question 12

Respiratory Syncytial Virus
Family
Genome
Virion

Answer 12

Paramyxovirus
(-)ssRNA
Enveloped

Question 13

Respiratory Syncytial Virus infects these cells

Answer 13

ciliated cells of respiratory epithelium

Question 14

Respiratory Syncytial Virus significance

Answer 14

Most important viral agent for pediatric respiratory infections

Question 15

Respiratory Syncytial Virus replication

Answer 15

limited to respiratory tract

Question 16

Respiratory Syncytial Virus incubation period

Answer 16

4-5 days

Question 17

Respiratory Syncytial Virus immunity

Answer 17

Not life long b/c slow immune response

Question 18

Respiratory Syncytial Virus prevention

Answer 18

No antivirals
No faccine
Passive immunoprohlaxis (humanized antibody)

Question 19

Varicellla zoster virus
Family
Genome
Virion

Answer 19

Alphaherpesvirus
dsDNA
Enveloped

Question 20

Varicellla zoster virus disease

Answer 20

chickenpox

Question 21

Varicellla zoster virus proteins

Answer 21

Hundreds of proteins

Question 22

Varicellla zoster virus

Replication

Answer 22

Needs active cell

Question 23

Varicellla zoster virus

Infection

Answer 23

inhalation of aerosolized droplets

Question 24

Varicella zoster Incubation period

Answer 24

10-21 days

Question 25

Chickenpox vs small pox

Answer 25

Chicken: Trunk and face small: arms and legs

Question 26

Chickenpox prevention

Answer 26

Vaccination: life long immunity Antivirals: cannot eliminate latent virus

Question 27

Poliovirus replication

Answer 27

In cell Creates pore in cell membrane Primary replicaiton in peyers of Small I. not bad Secondary: major viremia, gray matter replication

Question 28

Polio complications

Answer 28

CNS involvement Replication in gray matter of brain and spinal cord Limb paralysis from anterior horn Respiratory paralysis from medulla oblongata

Question 29

Polio Vaccination

Answer 29

Salk: killed Sabin: live attenuated

Question 30

Polio reservoirs

Answer 30

Only humans

Question 31

Rotavirus Family Genome Virion

Answer 31

Reoviridae dsRNA: 11 segments Non enveloped

Question 32

Rotavirus replication

Answer 32

In cell | Receptor mediated endocytosis

Question 33

Rotavirus unique feature

Answer 33

Genome never exposed

Question 34

Rotavirus incubation period

Answer 34

2 days

Question 35

Rotavirus symptoms

Answer 35

Vomiting and fever for 2 days | Diarrhea for another 3-8

Question 36

Rotavirus diagnosis

Answer 36

antigens in stool

Question 37

Rotavirus prevention

Answer 37

Infant vaccines No antivirals Hygiene Oral rehydration