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Micro 2 > L22 Chlamydia > Flashcards

L22 Chlamydia Flashcards

1
Q

Chlamydia
Gram
Special

A

Negative

No peptidoglycan

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2
Q

Chlamydia growth

A

Obligate intracellular

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3
Q

Chlamydia species

A

Trachomatis (human)
Pneumoniae (human)
psittaci
pecorum

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4
Q

Chlamydia is leading cause of

A

blindness

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5
Q

Chlamydia infectious dose

A

Small

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6
Q

Chlamydia infects what type of cells

A

mucosal epithelial

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7
Q

Chlamydia spread by

A

Fingers
Flies
Fomites
Fornication

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8
Q

C. trachomatis symptoms

A

Male: prostitis, epididymitis
Women: usually asymptomatic
cervicitis, newborn eye infetion

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9
Q

C. trachomatis infant infection leads to

A

conjunctivitis

pneumonia

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10
Q

Chlamydia development

A

Elementary body enters epithelial cells

Turns to reticulate bodies which multiple

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11
Q

How do EB get into cells

A

receptor mediated endocytosis

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12
Q

How do EB modify the vesicle

A

maintain pH above 6.2
Prevent fusion with lysosome

Also adds glycolipids for camouflage

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13
Q

RB divide by

A

binary fission

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14
Q

Chlamydia development

A

Slow (2-3 days per cycle)

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15
Q

RB nutrientt uptake

A

drinking staws that allow nutrient uptake without exiting inclusion vacuole

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16
Q

Lymphogranuloma venerum significance

A

systemic, spreads to other areas

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17
Q

Chlamydia pneumoniae can be observed in 40-100% of patients with

A

atherosclerotic heart lesions

18
Q

Layers to penetrate for chlamydia treatment

A

plasma membrane
inclusion membrane
chlamydial outer membrane
chlamydial cytoplasmic membrane

19
Q

Rickettsiae
Gram
special

A

Gram -

obligate intracellular bacteria

20
Q

Rickettsiae vs chlamydia

A

Rickettsiae capable of independent metabolism but just need host for replication

21
Q

Rickettsiae transmission

A

tick bite

22
Q

Rickettsiae ticks

A

Rocky mountain wood tick

American dog tick

23
Q

Rickettsiae attach to ____ cells

A

vascular endothelial cells (small blood cells)

24
Q

Once inside the cell Rickettsiae…

A

lyse phagosome (phospholipase) and enter cytosol

25
Q

R. prowazekii exits cell by

A

lysis

26
Q

R rickettsii exits cell by

A

using host actin to be pushed out of filopodia

27
Q

R. tsutsugamushi exits cell by

A

budding thru cell membrane (remains enveloped in host cell membrane as it infects other cells)

28
Q

Injury to host from Rickettsiae is dictated by

A

number of intracellular bacteria

29
Q

Rickettsiae symptoms

A

hemorrhagic spots from cell lysis

30
Q

R. prowazekki disease

A

Recrudescent typhus

31
Q

R. typhi disease

A

Murine typhus

32
Q

Why is diagnosing rickettsioses problematic?

A

no fever and not aware of tick bite

33
Q

Ricketts diagnostic tests

A

Antibody titers

34
Q

Mycoplasma significance

A

small organism capable of growth on cell free media

35
Q

Mycoplasma requires

A

sterol

36
Q

Mycoplasma appearance

A

fried egg
small colonies
slow growth

37
Q

Mycoplasma species

A

M. pneumoniae
M. genitalium
M. hominis
Ureaplasma urealyticum

38
Q

True or false: some mycoplasma are part of normal human flora

A

True

39
Q

M. pneumoniae significance

A

Walking pneumonia

Primary atypical pneumonia: not cleared by penicillin

40
Q

M. Pneumoniae and penicillin

A

no meurin so not cured by penicillin

Micro 2 (11 decks)

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