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Micro 2 > L29 Antivirals > Flashcards

L29 Antivirals Flashcards

1
Q

Enfuvirtide disease

A

HIV

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2
Q

Enfuvirtide path

A

blocks refolding of gp41

Inhibits membrane fusion for ENTRY

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3
Q

Amantadine disease

A

infuenza

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4
Q

Amantadine path

A

blocks M2 ion channel

preventing nucleocapsid release at end of ENTRY (uncoating)

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5
Q

Rimantadine disease

A

influenza

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6
Q

Rimantadine path

A

blocks M2 ion channel

preventing nucleocapsid release at end of ENTRY (uncoating)

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7
Q

Acyclovir disease

A

herpes

Most effective against HSV1,2

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8
Q

Acyclovir type

A

nucleoside analogue preventing REPLICATION (nucleic acid synthesis)

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9
Q

Acyclovir specificity depends on

A

Virus thymadine kinase

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10
Q

Ganciclovir disease

A

CMV

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11
Q

Gangciclovir vs Acyclovir

A

Works on CMV but more toxic due to cellular kinases

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12
Q

Valganciclovir vs Acyclovir

A

Both treat HSV but has improved bioavailability

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13
Q

Acyclovir hurdles

A

Bioavailability

Specificiity on virus Thymadine Kinase

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14
Q

Foscarnet disease

A

Herpes

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15
Q

Foscarnet path

A

Prevent viral polymerase activity preventing REPLICATION (nucleic acid synthesis)

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16
Q

Foscarnet downfalls

A

IV administration

Toxic

17
Q

Nucleoside inhibitors for HIV and HepB negatives

A

Toxic
Resistance
Usually includes more than one

18
Q

Ribavarin disease

A

RNA viruses

19
Q

Ribavarin mechanisms

A

Triphosphate inhibits polymerase
Monophasphate inhibits inosine monophosphate dh
Impaires capping of mRNA

20
Q

Ritonavir disease

A

HIV

21
Q

Ritonavir path

A

Block Gag-Pol cleavage
Boosts protease inhibitors
Prevents PROTEASE (late protein processing)

22
Q

How to prevent virus release

A

Neuraminidase inhibitors

23
Q

Bioavailability components

A

Absorption into body
Transport to site
Intake by cell
Half life

24
Q

Neuraminidase inhibitor disease

A

Influenza..virus release

25
Q

Interferons are more effective against ___ than ____

A

RNA viruses than DNA viruses

26
Q

Killed vaccine disadvantages

A

does not induce cell mediated immunity
protection is shorter
usually injected

27
Q

Polio vaccine complication

A

Vaccine acquired paralytic poliomyelitis VAPP

We only use the killed vaccine

28
Q

Immune cells important for vaccination

A

B cells
CD8 T-cells
CD4 T-cells

29
Q

Vaccines utilizing B cells only

A 
pneumonococcal
Influenza B (HIB)
30
Q

Vaccines utilizing B and T cell including ____

A

Including IgA
Influenza
Polio
Oral typhoid

Micro 2 (11 decks)

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