L29: Paramyxoviridae (Romero) Flashcards
Peste des petits ruminants virus (PPRV) chars.
- highly infectious dz of goats and sheep
- similar to Rinderpest
- wildlife doesn’t play role in its spread
- effects goats more than sheep
- NOT zoonotic
- targets lymphoid and epithelial tissues of GI and resp. tracts
trans. of Peste des petits ruminants virus (PPRV)
-direct contact (worse in confinement)
lesions of Peste des petits ruminants virus (PPRV)
- severe conjunctivitis and stomatitis
- abomasum frequently involved**
- Peyer’s patches severely affected
- LI shows severe congestion along the mucosal folds known as “zebra striping”**
FINAL Dx of Peste des petits ruminants virus (PPRV) performed where?
Plum Island
Control of Peste des petits ruminants virus (PPRV)
- notifiable
- tx for bacteria/parasites
- vaccinate
Bovine parainfluenza virus type 3 (BPIV-3)
Complex of viral pathogens including: -Bovine respiratory syncytial virus -Bovine herpesvirus-1 -Bovine viral diarrheal virus -Bovine resp. coronavirus -Bovine parainfluenza Accounts for 75% of health problems in cattle! Trans. by resp. aerosols/fomites Worldwide
CS of Bovine parainfluenza virus type 3 (BPIV-3)
- coughing, nasal d/c, fever
- immunosuppression –> bronchitis, pneumonia
Path. of Bovine parainfluenza virus type 3
- targets epithelial cells of the resp. tract
- induces inflammation and necrosis in lung airways
- impairs mucociliary clearance from airways
- intracytoplasmic/intranuclear inclusion bodies may be present
Dx of Bovine parainfluenza virus type 3
isolation/immunofluorescence/RT-PCR/Serology
Is BPIV-3 a hemagglutinating virus?**
Yes
immunological features of Bovine parainfluenza virus type 3
- H,N, and VN Ab develop after infection
- animals may be re-infected
- Colostrum Ab prevent clinical dz
- vax work better in dairy than beef cattle
Bovine respiratory syncytial virus chars.
- most common and important cause of lower resp. tract disease in cattle
- occurs worldwide
- more serious in calves
- also effects sheep/goats
-most common and important cause of lower resp. tract disease in cattle
Bovine respiratory syncytial virus
Path. of Bovine respiratory syncytial virus
- destroys ciliated epithelium of the airways in the lung
- pneumonia, emphysema
Dx of Bovine respiratory syncytial virus
-RT-PCR is best**
Prevention of Bovine respiratory syncytial virus
-vaccination (won’t completely prevent infection, but will help)
Avian metapneumovirus sub-types
A/B: everywhere except USA
C: USA
D: France
-Australia and NZ are free of all sub-types
-Cross-neutralization is possible between sub-types A and B
CS of Avian metapneumovirus
Turkeys: nasal d/c, peritonitis, air sacculitis, pneumonia, pericarditis, perihepatitis, etc.
Chickens: swollen head syndrome, swelling of infraorbital sinuses
economic impact of Avian metapneumovirus
- poor food conversion
- 2ary bacterial infections
- drop in egg production
Dx of Avian metapneumovirus
- detect viral genome
- Ab/Ag detection
- virus isolation
Vax against Avian metapneumovirus
Young meat turkeys: live-attenuated
Breeders/Layers: live-attenuated and inactivated vaccines