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Virology (Fall 2014) > L22: Adenoviridae and Papillomaviridae (Cortes-Hinojosa) > Flashcards

L22: Adenoviridae and Papillomaviridae (Cortes-Hinojosa) Flashcards

1
Q

Adenovirus structure

A
  • non-enveloped
  • dsDNA
  • very stable
  • INTRANUCLEAR replication
  • diverse (species specific)
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2
Q

Dx and tx of adenoviruses

A

Dx: EM, PCR to speciate
Tx: Cidofovir in mammals

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3
Q

transmission of canine adenovirus-1/infectious canine hepatitis

A

ingestion/inhalation of bodily secretions

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4
Q

Clinical forms of canine adenovirus-1/infectious canine hepatitis

A

MODERATE: depression, lethargy, blue eye, anorexia, pale mm, abd. pain, etc. (recover in 4-7d)
SEVERE: bleeding gums, bloody d, shock, coma (death 3-5d later)
SUDDEN DEATH: fever, depression, sudden death (no warning)

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5
Q

Dx of infectious canine hepatitis: CBC/Chem

A
  • leukopenia –> leukocytosis
  • L shift
  • initially high liver enzymes
  • hypoglycemia
  • hypoalbuminemia
  • hyponatremia
  • hypokalemia
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6
Q

Dx of infectious canine hepatitis: Urinalysis

A
  • proteinuria (due to acute glomerular injury)
  • casts
  • bilirubinuria
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7
Q

Dx of infectious canine hepatitis: misc. labs

A
  • high bile acids
  • prolonged coag test
  • schistocytes
  • PCR best specific dx option**
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8
Q

prognosis of infectious canine hepatitis

A
  • lifelong immunity if recover

- can prevent with vaccine for adenovirus-2 vaccine, proper hygiene

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9
Q

4 causes of Canine Infectious Tracheobronchitis Complex (Kennel Cough)

A
  • Bordetella bronchiseptica
  • Canine parainfluenza virus
  • Canine distemper virus
  • Canine adenovirus-2
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10
Q

chars. of Canine Adenovirus-2

A
  • contributor to kennel cough
  • highly contagious, esp. in crowded/humid/stressful environments
  • transmitted by direct contact or contaminated fomites
  • effects young dogs more
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11
Q

CS of Canine Adenovirus-2

A

dry/hacking cough

afebrile

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12
Q

Dx/Tx of Canine-Adenovirus-2

A

Dx: Based on CS and Hx (presumptive)
Tx: rest, +/- cough suppressants. Abx if 2ary bacterial infection

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13
Q

Prevention of Canine Adenovirus-2

A

Vaccine (DAPP = distemper, adenovirus, parvovirus, parainfluenza)
Good husbandry, isolation, disinfection

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14
Q

Mastadenovirus

A
  • an equine adenovirus (also found in pigs, camelids)
  • EqAdV1 serotype –> respiratory
  • EqAdV2 serotype –> gastrointestinal
  • Dx: PCR
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15
Q

Atadenovirus

A
  • hemorrhagic dz in cervids
  • Dx: PCR/Sequencing
  • causes Egg Drop Syndrome
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16
Q

what dz does Siadenovirus cause?

A

turkey hemorrhagic enteritis/marble spleen disease

17
Q

Name 3 poultry adenoviruses

A

Aviadenovirus
Atadenovirus
Siadenovirus

18
Q

Papillomavirus structure

A
  • non-enveloped capsid
  • dsDNA
  • INTRANUCLEAR replication
  • diverse (but not host specific)
19
Q

Do adenoviruses/papillomaviruses use intranuclear inclusions?

A

Y

20
Q

basic virus structure of adenoviruses and papillomaviruses

A

adeno: linear
papillo: circular

21
Q

Canine Oral Papillomatosis etiology/CS

A
  • can be caused by various papillomaviruses

- causes wartlike lesions in mouth

22
Q

Dx of canine oral papillomatosis

A
  • distinguish from neoplasia, eosinophilic granuloma, epulides
  • biopsy
  • EM, PCR
23
Q

Tx/prevent. of canine oral papillomatosis

A

Tx: resolves on own, cryotherapy, sx
Prevent: avoid contact with infected animals

24
Q

Feline Papillomavirus type FcPV1 assoc. with:

A

oral papillomatosis

25
Q

Feline Papillomavirus type FcPV3/4 assoc. with:

A

sarcoids

26
Q

Bovine Papillomatosis chars.

A
  • at least 10 types
  • infect genitalia, skin
  • found in wild animals in Africa
27
Q

Equine Sarcoids chars.

A
  • common!
  • due to Bovine papillomavirus 1,2
  • causes firm lesions anywhere on body
  • classified as verrucous, fibroblastic, mixed, or occult
28
Q

Dx/Tx of Equine Sarcoids

A

Dx: CS, biopsy
Tx: verrucous/occult usually not treated and may –> fibroblastic; sx +/- irradiation, chemo, cryotherapy, etc.

29
Q

Equine Papillomaviruses

A

EcPV2 type causes genital squamous cell carcinom

30
Q

Equine Warts trans/CS/Dx/Tx

A

-effects young horses most
-trans: direct contact/fomite
-CS: wart-like lesions usually around muzzle
Dx: CS/biopsy
Tx: resolve on own or have underlying immune dz; cryosurgery, cautery

Virology (Fall 2014) (15 decks)

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