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a. SL12100: Health and disease > L22 - Autonomic Nervous System > Flashcards

L22 - Autonomic Nervous System Flashcards

1
Q

What are innervates tissue that are not under voluntary control?

A
  • smooth muscle
  • glandular tissue
  • cardiac muscl
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2
Q

What is the ANS divided into?

A
  • sympathetic - fight or flight
  • parasympathetic - rest and digest
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3
Q

What is the organisation of efferent fibres in the sympathetic ANS?

A
  • short preganglioinic fibres
  • sympathic gangliom
  • long postganglionic fibre
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4
Q

What is the organisation of efferent fibres in the parasympathetic ANS?

A
  • long preganglionic fibres
  • parasympathetic ganglion
  • short postganglionic
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5
Q

What do preganglionic neurons generally project to in the SANS?

A

Paravertebral sympathetic chain

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6
Q

What do postganglionic neurons generally send to in the SANS?

A

Long axonal projection that synapse on the target organ

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7
Q

What do preganglionic neurons generally send to in the PANS?

A

Long axonal projection to parasympathetic ganglia
- in or near target organ

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8
Q

What do postganglionic neurons generally send to in the PANS?

A

Short axonal projection which synapse on target organ

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9
Q

What does the sympathetic division to the body? (10)

A
  • dilates pupil
  • inhibits salivation and tearing
  • constrict blood vessels
  • relaxes airway
  • accelarates hearbeat
  • stimulates glucose prod and release
  • inhibits digestion
  • stimulates secretions of (nor)epinephrine from adrenal medulla
  • relaxes urinary bladder
  • stimulates orgasm
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10
Q

What does the parasympathetic division to the body? (9)

A
  • constricts pupil
  • stimulates salivation and tears
  • constricts airways
  • slows hearbeat
  • stimulates digestion
  • stimulates pancreas to release insulin/digestive enzymes
  • dilates blood vessels in gut
  • stimulates urinary bladder to contract
  • stimulates sexual arousal
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11
Q

What are somatic efferent neurotransmitters and receptors like in the ANS?

A

Pre - Ach - NIC

Skeletal muscle

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12
Q

What are sympathethic neurotransmitters and receptors like in the ANS?

A

Pre - ACh - NIC
NA - Adr
- Heart, blood vessels, etc.

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13
Q

What are exceptions to the sympathetic neurotransmitters and receptors in the ANS?

A

Sweat glands
Pre - ACh - NIC
ACh - Musc

Adrenal medulla
Pre - Ach - NIC

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14
Q

What are parasympathetic neurotransmitters and receptors like in the ANS?

A

Pre - ACh - NIC
ACh - Musc

  • Hear, smooth muscle, sweat glands, etc
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15
Q

What type of receptors are adrenoceptors and muscarinic receptors?

A

G-protein-coupled

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16
Q

What are the different ypes of G-protein-coupled receptors?

A
  • Gs-coupled
  • Gi/Go-coupled
  • Gq-coupled
17
Q

What do Gs-coupled receptors do?

A

activate adenylate cyclase
- production to cAMP

18
Q

What does Gi/Go coupled receptors?

A

Inhibits adenylate cyclase
- also effects on ion channels

19
Q

What do Gq-coupled receptors do?

A

activate phospholipase C
- production of IP3

20
Q

What are the different types of adrenoceptor subtypes?

A
  • alpha
  • beta
21
Q

What are the agonist and antagonists of alpha adrenoceptors?

A
  • NA>A
  • phenotalime
22
Q

What are the agonist and antagonists of beta adrenoceptors?

A
  • A>NA
  • propanolol
23
Q

What are the subtypes of alpha adrenoceptors?

A
  • alpha1
  • alpha2
24
Q

What is the coupling and main actions of alpha1?

A
  • inc in PLC and IP3
  • vasoconstriction
  • relaxes GI tract
25
Q

What is the coupling and main actions of alpha2?

A
  • dec adenylate cyclase
  • inhibits NA release
26
Q

What are the subtypes of beta adrenoceptors?

A
  • beta1
  • beta2
  • beta3
27
Q

What is the coupling and main actions of beta1, 2 and 3?

A
  • inc adenylate cyclase
  • inc heart rate
  • bronchodilation, vasodilation
  • lipolysis
28
Q

What are the different subtypes of muscarinic receptors?

A
  • M-1
  • M-2
  • M-3
29
Q

What type, location and coupling does M-1 have?

A
  • neural
  • CNS
  • inc IP3
30
Q

What type, location and coupling does M-2 have?

A
  • cardiac
  • heart
  • dec cAMP
31
Q

What type, location and coupling does M-3 have?

A
  • glandular
  • smooth muscle
  • inc IP3

a. SL12100: Health and disease (30 decks)

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