L14 antigen presentation and costimulation Flashcards
what molecules help MHC I/TCR and MHC II/TCR interactions
CD4 and CD8 T cells
what is stable adhesion acheived by
ICAM-1 on the DC to LFA-1 on the T cell
what does CD8 assist in binding of
TCR and MHC I
what does CD4 assist in the binding of?
TCR to MHC II
what is the initial trigger (signal 1) that turns LFA-1 from a low affinity to high affinity binding state
the binding of TCR to MHC
are MHC to TCR interactions weak or strong
weak
what does weak interaction allow for ?
serial triggering
what is the name for the co stimulater molecule of CD28
B7 or CD80
when does an antigen-presenting cell present CD80
if they have been activated by a pathogen
what makes a T-cell active/fully activated
when enough TCR have been triggered by MHC
what do co stimulater molecules do?
guard againest inappropriate immune responses
what happens in the central SMAC
serial triggering
why does serial triggering occur in the central SMAC
The adhesion molecules are out to the side
what occurs at the peripheral SMAC
adhesion between the ICAM-1 and LFA-1 molecules
components of the SMAC
central
peripheral
distal
