L12

Question 1

What are the three main types of connective tissue fibers

Answer 1

Collagen reticular elastic

Question 2

The main fiber

Answer 2

Collagen

Question 3

Most abundant protein

Answer 3

Collagen

Question 4

Provides tensile strength

Answer 4

Collagen

Question 5

Found in the bones Denton tendons and dermis

Answer 5

Collagen type one

Question 6

Contains two alpha chains that are identical and one different alpha chain

Answer 6

Collagen type one

Question 7

Present mainly in hyaline & elastic cartilages

Answer 7

Collagen types to

Question 8

Forms very thin fibrils

Answer 8

Collagen type two and three

Question 9

Has three identical Alpha chains

Answer 9

Collagen type two

Question 10

Associated with Collagen type1

Answer 10

Collagen type three

Question 11

What is the major collagenase component of reticular fibers

Answer 11

Collagen type three

Question 12

can co-polymerize with other types of collagen

Answer 12

Collagen type three

Question 13

Found in the basal lamina of epithelial & endothelial cells

Answer 13

Collagen type 4

Question 14

What’s two types of collagen that do not form fibrils 

Answer 14

Type 4 and 7

Question 15

meshwork of procollagen

Answer 15

Type 4

Question 16

Support /filtration in the basal lamina

Answer 16

Type4

Question 17

Anchors basal lamina to the underlying type one and type two collagens of lamina reticularis

Answer 17

Type7 (anchoring proteins)

Question 18

fibroblast, chonderioblast, osteoblasts and odntoblasts. Produces ___
Fibroblast/ reticular cells produce ___ 
Fibroblast and smooth muscle cells produce ___

Answer 18

Collagen
Reticular
Elastin

Question 19

What are the three principle amino acids that make up collagen and their percentage

Answer 19

Glycine 33%, proline 12% and hydroxyproline 10%.

Question 20

Each molecule is composed of___ subunit polypeptide

Answer 20

3

Question 21

The three alpha subunits in the polypeptide are held together by

Answer 21

Hydrogen bonds

Question 22

Each complete turn of the helix spans distance of___ nm.
The length of each tropocollagen is ___ nm and width is ___ nm.

Answer 22

8.6

280

1.5

Question 23

Flexible, unbranched, high tensile strength

Answer 23

Collagen Fibers

Question 24

Click for a note

Answer 24

Tropocollagen&raquo_space;fibrils ( bound by non- fibrillar collagen and proteoglycans)&raquo_space; fibers

Question 25

Provide tissues with ability to respond to stretch and distension

Answer 25

Elastic Fibers

Question 26

interwoven with collagen to form a 3 dimensional network

Answer 26

Elastic Fibers

Question 27

Fibers are thinner than collagen

Answer 27

Elastic Fibers and reticular

Question 28

desmosine & isodesmosine

Answer 28

Unique elastin amino acids

Question 29

What type of bonds hold elastin molecules together

Answer 29

Covalent bond

Question 30

Elastin lacks

Answer 30

Hydroxylysine

Question 31

Elastin is rich in

Answer 31

Proline and glycine

Question 32

Elastin is poor in

Answer 32

Hydroxyproline

Question 33

Why is elastin hydrophobic

Answer 33

Because it is rich with glycine 

Question 34

Ground substance of connective tissue is produced by

Answer 34

Fibroblast

Question 35

What helps determine the consistency of the matrix

Answer 35

The ground substance

Question 36

What are the three large molecules in the ground substance

Answer 36

condroitin sulfate > support

hyaluronic acid ( mainly) > thick, viscous, slippery

adhesion proteins> binds collagen fibers to ground substance.

Question 37

Explain the structure of proteoglycans

Answer 37

Core protein with GAGs at the top, hylaronic acid at the bottom linked to it by linker protein

Question 38

Deficiencies in this type of collagen leads to :
Collagen Type I
Collagen type III
Collagen Type IV
Collagen Type VII

Answer 38

OI
EDS
AS (kidneys)
Kindler’s syndrome (skin)

Question 39

What binds fibers to GS

Answer 39

Anchoring proteins present in ground substance