L1 Host and parasite relationship intro Flashcards

1
Q

What is Infectious Disease?

A

an infectious disease is any change from a state of health in which part or all of the host’s body cannot carry on its normal functions because of the presence of an infectious agent or its products

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2
Q

Explain how an infectious disease is like a battle

A

the host provides protection, nutrients and energy
 pathogen must:
access and exploit the host
access new hosts
 the host must resist infection

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3
Q

Parasitism

A

symbiotic interaction between two organisms in which one benefits at the expense of the other

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4
Q

Parasites characteristics

A
  •  live on or within a host organism
  •  use the host to achieve metabolism (‘dependence’)
  •  parasite benefits from the association
  •  host is usually harmed
  •  typically cause disease in the host
  •  the term includes bacteria, viruses, fungi, protists
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5
Q

Microbiome in human features

A

protective function, development and maturation of the immune system, regulatory function of the nervous system, metabolic and nutritional function.

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6
Q

Microbiota dysbiosis

A

lead to dysregulation of bodily functions and diseases including cardiovascular diseases, cancers, respiratory diseases, etc.

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7
Q

Infection

A

the parasite grows and multiplies in or on its host

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8
Q

Infectious disease (an outcome)

A

where infection detrimentally affects host function

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9
Q

Pathogen

A

any organism causing infectious disease

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10
Q

Types of pathogens

A

Primary and opportunistic

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11
Q

Primary pathogens -

A

cause infectious disease in healthy hosts

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12
Q

Opportunistic pathogens -

A

cause infectious disease in ‘compromised’ hosts, e.g., immunocompromised or
wounded hosts; may be part of the normal microbiota (normal flora)

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13
Q

Pathogenicity

A

the ability to cause disease

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14
Q

Virulence

A

the degree or intensity of pathogenicity e.g., indicated by fatality rate or ability to damage host tissues

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15
Q

What does it mean when some pathogens can enter a latent state

A

The pathogen is present, but no symptoms are evident (chicken pox/varicella)

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16
Q

The infectious Disease Process

A
  1. Incubation period
  2. Prodromal stage
  3. Illness period
  4. Convalescent period (or death)
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17
Q

Infection process: Incubation period

A
  • Time from pathogen entry to development and the signs and symptoms (little to none)
  • Pathogen development but no clinical manifestations
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18
Q

Infection process: Prodromal Stage

A
  • Non-specific clinical manifestations may appear like tiredness.
  • Patient may be contagious
19
Q

Infection process: Illness period

A
  • Disease most severe
  • Characteristic signs and symptoms of the illness
  • Immune response triggered
20
Q

Infection process: Convalescent period (or death)

A

This is the recovery phase and where signs and symptoms will decline

21
Q

Incubation periods

A
  • Short (<1 week): localised infections - e.g., Dengue
  • Medium (7-21 days): generalised infections, e.g., Measles
  • Long (weeks to months) – e.g., Rabies
  • Very long (years): Usually fatal – e.g., prion diseases
22
Q

List: Patterns of infection

A
  • Acute
  • Latent
  • Chronic
  • Insidious
23
Q

Patterns of infection in detail

A
  • Acute non-persistent – rapid and self-limiting
  • Latent – persistence of viralgenome in the host cell and periodic virus reactivation
  • Chronic - persistent or otherwise long-lasting
  • Insidious infections
    with fatal outcomes
24
Q

The Infection Chain links

A
  1. Pathogen source/reservoir
  2. Transmission
  3. Infectious dose
  4. Exposure & growth
  5. Host susceptibility
  6. Exiting the host
25
Q

Infection chain: pathogen source/reservoir

A

Source - the location from which pathogen is transmitted to host. Can be
* Animate (human,plants,animals) like a cold
* Or inanimate (soil/water/food) like water/food-bourne
Reservoir - natural environmental location where the pathogen is normally found

26
Q

Can reservoir and source be different

A

yes example: Hendra virus (reservoir = bats;
source of human infection = horses)

27
Q

Infection chain: pathogen transmission (Airborne)

A

Via water droplets
 typically, infections with respiratory involvement e.g., colds, influenza,
tuberculosis, measles
 small particles (1-4 µm diameter)
 can remain airborne for long time
 can travel long distances
 propelled from respiratory tract by sneezing, coughing, or vocalization
 also, from reservoirs - e.g., Legionnaire’s disease (air-conditioning cooling
towers)
Via dust
 many systemic fungal infections
 can be source of hospital-acquired (nosocomial) infections

28
Q

Infection chain: pathogen transmission (Contact)

A

Pathogen source and host come into contact
Person-to-person
 touching, kissing, sex (e.g., HIV, gonorrhea, clamydia)
 oral or wound secretions (e.g., herpes)
 nursing mothers (e.g., staphylococcal infections)
 Placenta (vertical transmission) (e.g., syphilis)
Animal-to-person
 animal handlers e.g., Lyssavirus (wildlife bat handlers)

29
Q

Infection chain: pathogen transmission (Vehicle)

A

An inanimate ‘vehicle’ is a source that has become contaminated/transmits a
pathogen
Common vehicles are termed fomites*
 surgical instruments, drink containers, bedding,
door handles, taps
 food and water
 cosmetics
 drugs, needles
*Fomite is an inanimate object or substance that is
capable of transmitting infectious organisms

30
Q

Infection chain: pathogen transmission (Vector)

A

Vectors house infectious agents and transmit them one host to another, commonly acting as a host itself.

External transmission
 Passive carriage of pathogen on body of vector
 No growth of pathogen during transmission
e.g., Shigella dysenteriae (shigellosis): flies carry the bacterium on their feet from faecal sources to food
Internal transmission
 Pathogen carried within vector
e.g., the plague bacterium Yersinia pestis in rat fleas during transmission from rat to human
e.g., malarial parasite undergoes developmental changes in the mosquito vector

Most vectors are artropods

31
Q

Infection chain: Infectious Dose

A

Infectious dose 50 (ID50) = number of organisms necessary to infect 50% of an experimental group of hosts in a specified time period

32
Q

Infection chain: Exposure and Growth

A

Transmission alone is not enough for infection to occur pathogen must make contact with appropriate host tissues
 specific cell surface receptors for pathogen must be present
 pathogen must find appropriate conditions (nutrients, pH,
temperature etc.) to grow
Pathogens vary in the systems they affect in hosts
respiratory, urogenital, gastrointestinal, circulatory; some affect
multiple systems
Pathogens vary in their location in hosts
 extracellular pathogens grow outside cells in blood, tissue fluids
 intracellular pathogens grow and multiply within cells

33
Q

Facultative intracellular pathogens

A

= grow within or outside cells

34
Q

Obligate intracellular pathogens

A

= only grow when inside cells

35
Q

Infection chain: Host Susceptibility

A

Genetic or constitutional factors, specific immunity and nonspecific factors that affect an individual’s ability to resist infection or to limit pathogenicity.
2 components of defence mechanism :
* innate host resistance
* adaptive immune mechanism

36
Q

Infection chain: Exiting the Host

A

For microbe perpetuation
* active
- Movement through a portal of exit from the host
- Uncommon (borrowing out)
* Passive
- Common
- Excretions in faeces, urine, blood droplets, saliva or shedding of host cells

37
Q

List Microbial virulence factors

A
  1. Adherence and colonisation
  2. Invasion
  3. Avoiding/resisting host defences
  4. Toxin formation
38
Q

MVF: Adherence and colonisation

A

Help microbes to attach to host tissue. If attached and reproduction happens then host is colonised.
 fimbriae/pili (hair-like structures) of bacteria
 capsules (sticky polysaccharide materials) of
bacteria
 capsid spikes of viruses

39
Q

Determined by pathogen’s ‘virulence factors’

A

 can involve physical and chemical characteristics
 determine the degree to which the pathogen causes damage, invasion, infectivity

40
Q

Virulence

A

The magnitude of harm cause by a microbe, determined by virulence factors.

Different stains of the same microorganism can cause difference severity of diseases.

41
Q

MVF - Invasion

A

Pathogen spread from the site of infection.
* will vary among pathogens
* Pathogen can spread by producing chemicals that disrupt host cell surface or induce a cells uptake

42
Q

Virulence - avoiding/resisting host defenses

A
  • Microbes can be eliminated by the immune system
  • Pathogen can evade immune system
  • Bacterial pathogens can produce a sticky capsule that will coat the bacterium to prevent capture by immune cells (hepatitis B)
43
Q

Virulence - toxin formation

A

A toxin is a microbial product or component that injures another cell or organism

Bac. exotoxin secreted by proteins
Bac. endotoxin are bound to bacteria and released when the microorganism lyses or during cell division