Kidney

Question 1

Nephrotoxicity-

Answer 1

toxic to the kidney

Question 2

Things that can be nephrotoxic:

Answer 2

Antibiotics
Antineoplastics (Adrimycin, Cisplatin, methotrexate)
Antiinflamatory/analgesics (NSAID, acetominophen)
Diuretics (Organic mecurials)
Immunosuppressants
Dichloro ethane.
Episulfonium

Question 3

Metallothionein -

Answer 3

A protein that is bound to metals in the liver but then unbound by the kidney and so metals become in high concentrations there and couse Nephrotoxicity.

Question 4

Halogenated Hydrocarbons Nephrotoxicity-

Answer 4

metabolized in liver to glutathione conjugates, transported to the kidney, and re-activated.

Question 5

Aminoglycosides—

Answer 5

highly polar cations (reabsorbed by proximal tubule after binding to anionic lipids at cell surface—stored in lysosomes which eventually rupture)