Item 9 10 Flashcards
What are the antifungal drugs
AZOLES : (10)
Fluconazole
Ketoconazole
Itraconazole
Miconazole
Clotrimazole
Tioconazole
Voriconazole
Posaconazole
Oxiconazole
Nystatin
Amphoterecin B (only injectable )
Terbinafine ( new drug tab? Ointment)
Griseufluvin
Clinical indications of antifungal
FUNGAL Infections :
A) SYSTEMIC MYCOSES
I) Candiasis
2)Cryptococcosis
3) Aspergiollosis
B) SUPEERFICIAL MYCOSES
1) Tenia (skin hair nail )
2) Candiasis (skin mouth vagina
A/e of antifungals
Teratogenicity
Hepatotoxicity
Hypersensitivity
Neuritis
Vertigo
Headache
Dizziness
Blurring vision
Contraindications of antifungal
Pregnancy
Driver
Pilot
Hypersensitivity
Hepatotoxicity
Drugs used in leprosy
Antileprotic drugs
DAPSONE
RIFAMPICIN
CLOFAZIMINE
Ethionamide
Clarithromycin Ofloxacin Minocycline
Antihelminthic drugs
Albendazole
Mebendazole
Ivermectin
Levamysol
Pyrantel pamoate
Doses of anti helminthic drugs
TAB ALBENDAZOLE : 400mg —-1 tab First day (chewable ) then 1 tab at 7th day ( chewable ) {chewable}
TAB MEBNDAZOLE : 100mg —- Twice daily for 3 days {solas}
Amoebiasis
An infection caused by entamoeba histolytica produced by the ingestion of cysts of the organism
Classification of anti amoebic drugs
A) TISSUE AMOEBICIDES
For both intestinal and extra intestinal amoebiasis
Nitroimadazoles : Metronidazole
Orindazole
Secindazole
Tinidazole
For extra intestinal amoebiasis : only chloroquine
B) Luminal amoebicides
Amide : Nitazoxanide Diloxanide furoate
8- hydroxyquinolines = Diiodohydroxyquin Quinodochlor
Antibiotic = Tetracyclines
Common antiprotozoal drugs
Metronidazole
Orindazole
Secnidazole
Tinidazole
Nitazoxanide
M/A of metronidazole
Metronidazole
|
Enter into micro organism
|
Nitro group is reduced by ferrodoxins and Fe-S protein
|
Active metabolites
|
Breaks and damages microbial DNA
|
Death of organism
A/E of metronidazole
METALLIC TASTE IN TONGUE
Anorexia
Nausea
Vomiting
Epigastric distress and abdominal cramps
Headache
Dizziness
Ataxia
Vertigo
Neutropenia
Clinical Indications of Metronidazole
Amoebiasis
Any infection of lower extremity below umbilicus
Giardiasis
Trichomoniasis
PUD/ Triple therapy
Decubitus ulcer
Tetanus
Anaerobic infection in GUT
Septicemia
Pseudomembranous colitis
CONTRAINDICATIONS OF METRONIDAZOLE
Early pregnancy (12 weeks )
Lactating mother
Liver disease
Drugs used in KALA AZAR// Visercal leishmania cutaneous leishmania
Na stibogluconate
Miltefosine
Amphoterecin B
