Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Antidiabetic Drugs > Flashcards

Antidiabetic Drugs Flashcards

1
Q

Diabetes mellitus is

A

Condition characterised by hyperglycemia due to absolute or relative lack of insulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Type of DM

A

Type 1 IDDM or juvenile
Type 2 NIDDM
GDM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Anti diabetic drugs

A

Oral anti diabetic drugs
Injectable diabetic drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Oral anti diabetic drugs are

A

Oral hypoglycaemic drugs
Oral euglycemic drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Injectables

A

Insulin
Other agents

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Oral hypoglycaemic agents sulfonylurea group 1st gen

A

Tolbutamide
Chlorpropamide
Tolazamide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

2nd generation sulfonylurea group

A

Gliclazide
Glipizide
Glimepride
Glibenclamide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Disadvantage of 2nd gen

A

Minimum 30% B cell needed for their action

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Disadvantage of 2nd gen

A

Minimum 30% B cell needed for their action

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

A/E of sulphonylureas

A

Weight gain
Hypoglycemia
Chance of hyponatraemia
Renal impairment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Euglycemic agents are

A

Insulin sensitizers
Glucosidase inhibitors
Incretin mimetic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Insulin sensitizers

A

Biguanides : metformin , phenformin
Thia-zoli-dine-Diones = Pioglitazone , Rosiglitazone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Incretin mimetics dipeptidyl peptidase -4 enzyme inhibitor

A

Sitagliptin
Vildagliptin
Lindagliptin
Saxagliptin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Injectable Anti Dm drugs are

A

Insulin
Insulin analogues

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Insulin is

A

Secreted from B cell of islets of langerhans of pancreas
MW 5808
A chain has 21 @a
B chain has 30 @a

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Insulin conventional

A

Short acting : regular ( 6-8hrs )
Immediate acting = NPH lenter (12-18hrs )
Long acting = ultralente (24-36 hrs )

17
Q

Insulin analogues

A

Rapid acting = insulin Lispro , aspart , glulisine
Long acting = insulin glargine, detemir
Ultra long acting = degludec

18
Q

Indications of insulin

A

IDDM
NIDDM when OAD failure
GDM
DM with complications # diabetic keto acidosis # Hyperosmolar non ketotic state / COMA
# diabetic retinopathy # diabetic nephropathy
DM with severe infections
Pre operative and post operative management of DM patients
Management of hyperkelemia ( glucose potassium co transport )

19
Q

A/E of insulin

A

Hypoglycaemia
Insulin resistance
Insulin allergy
Lipodystrophy
Weight gain
Hypokalemia

20
Q

A/E of insulin

A

Hypoglycaemia
Insulin resistance
Insulin allergy
Lipodystrophy
Weight gain
Hypokalemia

21
Q

M/A of insulin

A

LIVER
(+) of hepatic glucose uptake
(-) of glycogenolysis
(-) of gluconeogenolysis

MUSCLE
(+) of glucose uptake and utilisation
(-) proteolysis
Gluconeogenesis

ADIPOSE TISSUE
increase glucose uptake
(-) lipolysis
(-) gluconeogenesis

22
Q

M/ A of glimepride

A

(+) b cell of pancreas —-release of insulin ——- decrease blood glucose by increase glucose uptake by cell

23
Q

M/A of sitagliptin

A

(-) dpp-4
No activation of glucagon like peptide 1 and gastric inhibitory peptide
Increase insulin level and glucagon level
Decrease blood glucose level
Anti DM action

24
Q

Management of hypoglycaemia

A

If patient can swallow = sugar sugar containing foods and glucose
If patient is unconscious = I/ v glucose or dextrose running 25% glucose in 100mil water

25
Q

Indications of metformin

A

NIDDM

Non diabetic patients = POLYCYSTIC OVARIAN DISEASE
OBESITY

26
Q

A/E of metformin

A

Anorexia
Epigastric discomfort
Diarrhoea
Lactic acidosis

27
Q

Metformin M/A

A

Increase glucose uptake in muscle and adipose tissue
Increase conversion of lactate from glucose
Decrease Glucose absorption from GIT
(+) glycolysis
Decrease plasma glucagon level
Reduced hypergylcemia
Anti diabetic action

28
Q

Metformin M/A

A

Increase glucose uptake in muscle and adipose tissue
Increase conversion of lactate from glucose
Decrease Glucose absorption from GIT
(+) glycolysis
Decrease plasma glucagon level
Reduced hypergylcemia
Anti diabetic action

Pharmacology (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions