Anti - Fubgal , Scabies ,leprosy, Amoebiasis Flashcards
Antifungal drugs are
AZOLES=
Fluconazole
Ketoconazole
Itraconazole
Miconazole
Econazole
Clotrimazole
Tioconazole
Voriconazole
Posaconazole
Oxiconazole
NYSTATIN
AMPHOTECERIN B
TERBINAFINE
GRISEUFULVIN
Clinical uses of antifungal drugs
Fungal infections (mycoses)
A) Systemic mycoses
Candidiasis
Cryptococcosis
Aspergiollosis
B) Superficial mycoses
Ring worm ( skin , hair, nail )
Candidiasis ( skin , mouth , vagina )
A/E of fluconazole / ketoconazole/ griseofulvin
HEPATOTOXICITY
TERATOGENECITY
NEURITIS
Vertigo
Headache
Dizziness
Blurring vision
Headache
Hypersensitivity
Contraindications of anti fungal drugs
Pregnancy
Driver
Pilot
Hypersensitivity
Hepatotoxicity
Drugs used in leprosy
DAPSONE
RIFAMPICIN
CLOFAZIMINE
Ethionamide
Ofloxacin
Clarithromycin
Minocycline
Antiviral drugs are
Acyclovir
Gancyclovir
Famcyclovir
Zidovudin
Lamivudin
Stavudin
Interferon
Amantadine
Rimantidine
Clinical uses of acyclovir
Herpes zoster
Herpes simplex
HIV infection / AIDS
Facial nerve palsy
Hepatitis
Influenzas
Antihelminthic drugs are
Albendazole ( 400mg 1 tab first day , 1 tab 7th day )
Mebendazole ( 100mg twice daily for 3 days )
Ivermectin
Levamysol
Pyrantel pamoate
Indications of anti helminthic
Ascariasis
Trichuriasis
Hookworm infestation
Hydatid disease
Enterobiasis
What is amoebiasis
Amoebiasis is an infection caused by entamoeba histolytica produced by the ingestion of cysts of the organism
Classification of antiamoebic drugs
TISSUE AMOEBICIDES
For both intestinal and extra intestinal amoebiasis
Nitroimidazoles = metronidazole , ornidazole, secnidazole , tinidazole
For extra intestinal amoebiasis only = chloroquine
LUMINAL AMOEBICIDES
Amide= nitazoxanide , diloxanide furoate
8-hydroxyquinolines= diiodohydroxyquin
Antibiotics = tetracycline
Common anti amoebic drugs are
Metronidazole
Ornidazole
Secnidazole
Tinidazole
Nitazoxanide
M/A of metronidazole
Metronidazole==> enter into micro organism ==> nitro group is reduced by FERREDOXINS and Fe-S protein ==> ACTIVE METABOLITES ==> breaks and damages microbial DNA==> Death of organism ( bacteriocidal action)
A/E of metronidazole
METALLIC TASTE IN TONGUES
VOMITTING
Anorexia
Nausea
Epigastric distress and abdominal cramps
Headache
Dizziness
Ataxia
Vertigo
Neutropenia
Indications of metronidazole
Amoebiasis ( amoebic dysentery , amoebic liver abscess)
Giardiasis
Trichomoniasis
Psedomembranous colitis
PUD/ triple therapy
Decubitus ulcer
Tetanus
Anaerobic infection in GUT ( before and after surgery )
Septicemia
