Invasive aspergillosis

Question 1

invasive pulmonary aspergillosis risk factors

Answer 1

seen in severe immunocompromised state due to prolonged neutropenia, chronic high dose steroid use, solid organ and allogenic stem cell transplant or AIDS

Question 2

classic triad of invasive pulmonary aspergillosis

Answer 2

cough, pleuritic chest pain and hemoptysis

Question 3

diagnosis of invasive pulmonary aspergillosis

Answer 3

CT chest with nodules and ground glass opacity (halo sign) or cavitations with air fluid levels
serum biomarkers: galactomannan, beta D glucan (70% specific) but can have false positives with blastomyces and histoplasma

sputum sampling for fungal stain and culture

Question 4

treatment of invasive pulmonary aspergillosis

Answer 4

voriconazole, reduction of immunosuppressive regimen

surgery if needed