Disseminated histoplasmosis

Question 1

disseminated histoplasmosis presentation

Answer 1

systemic fevers, chills, maliase
weight loss, cachexia
pulmonary cough and dyspnea

see mucocutaneous lesions (papules and nodules)

see reticuloendothelial (HSM and LAD)

Question 2

diagnosis of disseminated histoplasmosis

Answer 2

urine/serum histoplasma antigen
serology
culture takes
4-6 weeks

See CXR with reticulonodular and interstitial infiltrate

Lab findings: pancytopenia, transaminitis, and LDH and ferritin.

Question 3

TX of disseminated histoplasmosis

Answer 3

amphotericin B (moderate to severe dx)
itraconazole (mild dx/ maintenance)

Question 4

acute histoplasmosis presents as

Answer 4

febrile illness with respiratory symptoms and compatible imaging.