Introduction to Drug Action 🗸

Question 1

Pharmacology

Answer 1

the study of the manner in which the function of living tissues and organs is modified by chemical substances.

Question 2

pharmacological effect

Answer 2

what a drug does to the body

Question 3

pharmacokinetics

Answer 3

what the body does to a drug

Question 4

medicine

Answer 4

chemical preparation containing one or more drugs; therapeutic affect

Question 5

selectivity

Answer 5

the ability of a drug to distinguish between molecular targets within the body

Question 6

agonist

Answer 6

drug that binds to a receptor by producing a conformation change, to produce a cellular response
possess affinity and efficacy

Question 7

affinity

Answer 7

strength of association between ligand and receptor binding

Question 8

efficacy

Answer 8

ability of an agonist to evoke a cellular response (activation)

Question 9

antagonists

Answer 9

drugs that reduce or block the activations of an agonist by binding to the same receptor but they dont activate tyem
possess affinity but lacks efficacy

Question 10

potency

Answer 10

the amount of a drug needed to produce a desired affect

Question 11

efficacy

Answer 11

maximum response achievable by a drug

Question 12

EC50

Answer 12

concentration of agonist that elicits half maximal effect
easy to see using semi-log graph of concentration vs effect (sigmoidal relationship)

Question 13

Competitive antagonism

Answer 13

binding of agonist and antagonist occur around same (orthosteric) site - competitive
cause parallel right shift of agonist concentration response curve with no depression in maximal response

Question 14

non-competitive antagonism

Answer 14

agonist binds to normal site and antagonist binds to separate site (allosteric).
both may occupy sige simultaneously but activation cannot occur when antagonist is bound
no rightward shift but slope if depressed with maximum response curve