Intro Flashcards
pathophysiology
the systematic study of changes in the body physiology due to disease or injury
causes and influencing factors
etiology risk factors epidemiology growth and development determinants of heath levels of prevention
disease
an acute or chronic illness that one acquires or is born with that cause physiological dysfunction
illness
a person’s experience of a disease
epidemiology
the study of patterns of disease in a large group of people
incidence
number of new cases during a specific give
prevalence
existing disease at any given time
factors contributing to disease
risk factors
pre-disposing factors
predisposing factors
modifiable
non-modifiable
non-modifiable factors
heredity
age
gender
race
modifiable factors
smoking alcohol and drug abuse level of activity diet education socioeconomic status stress environment
interrelated aspects of disease
etiology > pathogenesis > clinical manifestations
clinical manifestations
signs and symptoms
signs
objective and measurable/ what you can see
symptoms
subjective/ what they feel
etiology
the study of the cause of disease
intrinsic
with the body
extrinsic
outside the body
idiopathic
unknown cause
iatrogenic
illness caused by medical treatment
types of genetic disorders
mutation
single gene disorder
aneuploidy
mutation
frame shift mutation
base pair substitution (frameshift are worst than base pair)
frame shift mutation
addition or deletion of one base pair
base pair substitution
one pair is substituted for another
aneuploidy
abnormal number of genes (normally 23 pairs of chromosomes)
Monosomy
turner syndrome
turner syndrome
single X chromosome
- 45 chromosomes
trisomy
klinefelter syndrome
Down syndrome
tripple X syndrome
XYY syndrome
klinefelter syndrom
XXY: 47 chromosomes
single gene disorder
caused by a single gene that is defective or mutated
autosomal recessive
must have 2 recessive genes for the disease to occur - both parents - 25% have
autosomal dominant
only need one dominant gene for the disease to occur - one parent - 50% have
x-linked
males inherit these types of diseases from their mothers and
females become carriers
multifactorial disorders
diseases caused y a number of genes acting together and influenced by environmental factors
ex.cancers
obstruction
anywhere there is a tube
- mechanical
- functional
- degeneration
- trauma
levels of prevention
primary
secondary
teritary
primary prevention
prevent disease from occurring
ex.sunscreen
secondary prevention
early detection
ex.screenings
tertiary prevention
prevent deterioration
mechanical obstruction
something physical that blocks
degeneration obstruction
wears down with time