Interstitial Lung Disease DSA II Flashcards
churg strauss syndrome
systemic necrotizing vasculitis
-upper and lower resp tracts
preceded by allergic disorders
peripheral and lung eosinophilia
IgE increase
rashes
CXR for churg strauss
bilateral patchy, fleeting infiltrates
diffuse nodular infiltrates
diffuse reticulonodular infiltrates
biopsy for churg strauss
granulomatous angiitis or vasculitis
Tx for churg strauss
corticosteroids
chronic eosinophilic pneumonia
pulmonary interstitium and alveolar spaces are infiltrated by eosinos and to lesser extent macrophages
clinical for chronic eosinophilic pneomonia
over weeks to months
-fever, weight loss, dyspnea, productive cough
pulmonary infiltrates with peripheral distribution
increased eosinophils in peripheral smear
BAL with increased eosinophils
Tx of chronic eosinophilic pneumonia
dramatic response to corticosteroids within days to weeks
therapy - prolonged for months - prevent recurrence
pulmonary alveolar proteinosis
primary path process affects alveolar spaces
filled with proteinacious phospholipid material
-components of surfactant
clinical for pulmonary alveolar proteinosis
dyspnea, cough, bilateral alveolar infiltrates
high res CT for pulmonary alveolar proteinosis
crazy paving pattern
thickened interlobular septa accompanied by groundglass alveolar filling
nocardia
superimposed resp infection
with pulmonary alveolar proteinosis
Tx for pulmonary alveolar proteinosis
whole lung lavage
good prognosis
whole lung lavage
gold standard treatment for pulmonary alveolar proteinosis
-saline into lungs with percussion to dislodge material in lungs
fluid then removed
repeated until no more material is recovered (when fluid is clear)
hypersensitivity pneumonitis
hyperimmune respiratory syndrome caused by inhalation of wide variety of allergic antigens that are usually rganic
bacteria, fungi, protozoa, animal proteins, reactive chemicals
Tx for hypersensitivity pneumonitis
avoid exposure
corticosteroids speed resolution
intermittent pulmonary and systemic symptoms, progressive interstitial CXR changes, non-resolving pneumonia
suspect hypersensitivity pneumonitis
agriculture, cattle farming, bird keeping, contaminated home ventilation, hot tubs
abrupt onset of cough, dyspnea, fever, chest pain, following heavy exposure to offending antigen, Sx 4-6 hours after exposure
subsides 24 hours after removal from exposure
acute hypersensitivity pneumonitis
gradula development of symptoms and less severe intensity
subacute hypersensitivity pneumonitis
insidious progressive dyspnea, cough, weight loss, fatigue, pulmonary fibrosis and resp failure
chronic hypersensitivity pneumonitis
thermophilic actinomycetes
moldy hay, grain, silage - farming - dairy cattle
hypersensitivity pneumonitis
also from ventilation - water-related contamination
-humidifier, hot tub, air conditioner