Immunology Flashcards
host defense in alveolar spaces
alveolar macrophages
Igs, opsonins, surfactants, lymphocyte mediated immunity, neutros and eosinos
sarcoidosis
increased lymphocytes
CD4 alveolitis
interstitial lung disease in smoker
carbonacesous macrophage
scleroderma
systemic sclerosis
neutrophils
eosinophils
idiopathic pulmonary fibrosis tx
corticosteroids not indicated
nonspecfic interstitial pneumonia tx
favorable response to corticosteroids
protective against radiation induced lung fibrosis
ACE
increased fibrosis
IGFBP5
increased fibroblast activity
endothelin 1
angiotensin II
anti-imflammatory and tissue repair promotion
TGF-beta
anti-proliferative
-promote epithelial mesenchymal transition
chronic expression - tissue fibrosis
source of TGF beta
alveolar macrophages in idiopathic pulmonary fibrosis
genetics of IPF
surfactant protein A2 and C
telomerase
MUC5B
systemic sarcoidosis
multisystem granulomatous
noncaseating epitheliod granulomas
depression of DTH response
sarcoidosis inflammatory response
TNF-alpha
IL-7
MMP-12
hypersensitivity pneumonitis immune response
higher in non-smokers**
lymphocytes, neutrophils, degranulated macrophages
hypersensitivity pneumonitis tx
corticosteroids aids recovery initially, long term outcome is unaffected
Th1 predominance in hypersensitivity pneumonitis
acute HP
Th2 predominance in hypersensitivity pneumonitis
subacute/chronic HP
eosinophilic lung disease
pulmonary infiltrates with eosinophilia
into airways, alveoli, interstitium
simple pulmonary eosinophilia
1-2 weeks
no resp failure
increased blood eosinos
BAL eisonos
chronic eosinophilic pneumonia
weeks to months
rare resp failure
increased blood eosinos
eosinos on BAL
acute eosinophilic pneumonia
1-5 days
frequent resp railure
no blood eosino elevation
BAL - eosinos, lymphocytes, neutrophils