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RESP II Exam 2 > Immunology > Flashcards

Immunology Flashcards

1
Q

host defense in alveolar spaces

A

alveolar macrophages

Igs, opsonins, surfactants, lymphocyte mediated immunity, neutros and eosinos

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2
Q

sarcoidosis

A

increased lymphocytes

CD4 alveolitis

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3
Q

interstitial lung disease in smoker

A

carbonacesous macrophage

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4
Q

scleroderma

A

systemic sclerosis

neutrophils
eosinophils

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5
Q

idiopathic pulmonary fibrosis tx

A

corticosteroids not indicated

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6
Q

nonspecfic interstitial pneumonia tx

A

favorable response to corticosteroids

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7
Q

protective against radiation induced lung fibrosis

A

ACE

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8
Q

increased fibrosis

A

IGFBP5

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9
Q

increased fibroblast activity

A

endothelin 1

angiotensin II

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10
Q

anti-imflammatory and tissue repair promotion

A

TGF-beta

anti-proliferative
-promote epithelial mesenchymal transition

chronic expression - tissue fibrosis

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11
Q

source of TGF beta

A

alveolar macrophages in idiopathic pulmonary fibrosis

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12
Q

genetics of IPF

A

surfactant protein A2 and C

telomerase

MUC5B

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13
Q

systemic sarcoidosis

A

multisystem granulomatous

noncaseating epitheliod granulomas

depression of DTH response

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14
Q

sarcoidosis inflammatory response

A

TNF-alpha
IL-7
MMP-12

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15
Q

hypersensitivity pneumonitis immune response

A

higher in non-smokers**

lymphocytes, neutrophils, degranulated macrophages

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16
Q

hypersensitivity pneumonitis tx

A

corticosteroids aids recovery initially, long term outcome is unaffected

17
Q

Th1 predominance in hypersensitivity pneumonitis

A

acute HP

18
Q

Th2 predominance in hypersensitivity pneumonitis

A

subacute/chronic HP

19
Q

eosinophilic lung disease

A

pulmonary infiltrates with eosinophilia

into airways, alveoli, interstitium

20
Q

simple pulmonary eosinophilia

A

1-2 weeks
no resp failure
increased blood eosinos
BAL eisonos

21
Q

chronic eosinophilic pneumonia

A

weeks to months

rare resp failure
increased blood eosinos
eosinos on BAL

22
Q

acute eosinophilic pneumonia

A

1-5 days
frequent resp railure
no blood eosino elevation

BAL - eosinos, lymphocytes, neutrophils

RESP II Exam 2 (23 decks)

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