Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

RESP II Exam 2 > Bronchodilators > Flashcards

Bronchodilators Flashcards

1
Q

prednisone

A

oral corticosteroid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

montelukast

A

leukotriene antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

zafirlukast

A

leukotriene antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

anti-IgE Ab

A

obalizumab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

bronchospasm

A

IgE on mast cells
-release histamine and other mediators

blocking single one - not very helpful

corticosteroids - block lots

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

preformed mediators

A

histamine
TNF alpha
protease
heparin

immediate

vasodilation, edema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

lipid mediators

A

minutes
leukotrienes, prostaglandins

mucus secretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

cytokines

A

interleukins, GM-CSF

hours

inflammatory cell proliferation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

IgE proliferation

A

IL-4, IL-5

Th2 cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

aerosol delivery

A

lots swallowed
-bets drugs - poor GI absorption

spacer - larger particles deposited before inhales - allows only smaller -which go to small airways

1-5 micrometers - get to small airways

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

DOC for rapid relief of bronchospasm

A

beta-adrenergic agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

beta agonist overuse

A

side effect intensify

seek help as soon as decline in efficacy of tx noticed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

asthma tx

A

control inflammatory component

bronchodialtor - sympomatic use PRN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

COPD tx

A

focus on reversible component

-bronchodilation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

no hand lung coordination

A

nebulizer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

SABA

A

albuterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

LABA

A

formoterol

salmeterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

emergency use

A

epinephrine - subQ

19
Q

beta agonist MOA

A

beta2 receptor

stimulate adenylyl cyclase and increase cAMP

relax bronchial smooth m, inhibit mediators of mast cells

20
Q

prevention of nighttime asthma attacks

A

salmeterol

prophylactic bronchodilation

slow onset - not for acute tx

21
Q

most effective long term treatment persistent asthma

A

inhaled corticosteroids

recommendations - long acting beta2 agonist in combination with inhaled corticosteroid

22
Q

beta agonist side effect

A

muscle tremor, cramps, tachyarrythmias, metabolic disturbanceq

23
Q

long term use of LABA

A

may down-regulate beta-2 receptors

lose protective effect

stop use once asthma control achieved and maintain use of an asthma-controller - inhaled corticosteroid

24
Q

anaphylactic rxn

A

epinephrine subQ

25
Q

quaternary muscarinic receptor antagonist

A

ipratropium bromide

inhaled aerosol

poor GI absorption** - swallowed little effect

26
Q

COPD tx

A

ipratropium

27
Q

long acting muscarinic antagonist

A

tiotropium

28
Q

theophylline

A

methylxanthine

  • adenosine receptor antagonist
  • PDE inhibitor
  • hyperpolarize cell membranes
29
Q

intranasal ipratropium

A

allergic rhinitis

postnasal drip syndrome

30
Q

methylxanthines

A

theophylline

cause bronchodilation

used to be first line for asthma - not less prominent role in therapy because benefits modest with narrow therapy index

31
Q

noctural asthma improvement

A

with slow release theophylline

but corticosteroids and salmeterol are probably better option

32
Q

PDE4 inhibitor

A

roflumilast
-for COPD

increased cAMP levels and reduce inflammation

reduced exacerbations

side effects - nausea, diarrhea, psych, weight loss

only pt not responding other therapy

33
Q

corticosteroid MOA

A

steroid receptor agonist
-to nucleus and +/- regulate gene transcription - takes time

inhibit lots of inflammatory mediators

34
Q

aerosol steroids

A

safer

35
Q

systemic corticosteroids

A

IV/oral - for severe asthma in hospital

prednisone/methylprednisone - IV then oral tapered off dose

36
Q

corticosteroid side effects

A 
HPA suppression
bone resorption
carb/lipids
cataracts
purpura
dysphonia
candidiasis
37
Q

combined products

A

fluticasone / salmeterol
budesonide / formoterol
mometasone / formoterol

38
Q

reversible component COPD

A

inflammation and bronchospasm

this is drug therapy

39
Q

irreversible component COPD

A

alveolar destruction

40
Q

COPD tx

A

inhaled ipratropium / tiotropium with beta2 agonist

monotherapy with inhaled corticosteroids - not approved for COPD

41
Q

growth retardation

A

concern with high dose corticosteroids in children

42
Q

triple therapy

A

for COPD
-tiotropium, LABA, corticosteroid

superior to 1 or 2 agents in relieving symptoms such as dyspnea and in improving lung function

43
Q

cromolyin

A

anti-inflammatory
-inhibit antigen-induced bronchospasm

inhibits release of histamine from mast cells

not effective in tx of ongoing or acute bronchospasm - primarly used as prophylactic**

44
Q

LTD4 receptor antagonist

A

motelukast
-oral prophylaxis for exercise induced asthma

alt tx for mild persistant asthma

RESP II Exam 2 (23 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions