INFLAMMATORY MUSCLE DISEASE

Question 1

INFLAMMATORY MUSCLE DISEASE
🌸 TYPES

Answer 1

⭐ POLYMYOSITIS
⭐ DERMATOMYOSITIS
⭐ JUVENILE DERMATOMYOSITIS
⭐ INCLUSION BODY MYOSITIS
⭐ IMMUNE MEDIATED NECROTISING MYOPATHY
⭐ CANCER ASSOCIATED MYOPATHY
⭐ ANTI-SYNTHETASE Syndrome
⭐ Amyopathic DERMATOMYOSITIS

Question 2

PAINLESS
➕
PROGRESSIVE
➕
SYMMETRICAL
➕
LOWER LIMB PREDOMINANT
➕
PERSISTANT SUBACUTE PROXIMAL WEAKNESS

Answer 2

Inflammatory MYOPATHIES

Question 3

Muscle Involvement in INFLAMMATORY MUSCLE DISEASE

Answer 3

1. Pharyngeal
   ⬇️
2. Esophageal
   ⬇️
3. Neck Flexors
   ⬇️
4. Respiratory Muscles

Question 4

GOLD STANDARD INVESTIGATION FOR INFLAMMATORY MUSCLE DISEASE

Answer 4

Muscle BIOPSY

Question 5

Investigation in INFLAMMATORY MUSCLE DISEASE

Answer 5

1. Muscle Biopsy
2. CPK ⬆️
3. Aldolase B
4. EMG
5. MRI of Thigh Muscle

Question 6

Age group: Juvenile DERMATOMYOSITIS

Age group: Adult onset DERMATOMYOSITIS

Answer 6

⭐ 5-15 yrs

⭐ 45-65 yrs

Question 7

F:M in DERMATOMYOSITIS

Answer 7

2:1

Question 8

Skin lesion in Dermatomyositis occurs by

Answer 8

6 months BEFORE Weakness

Question 9

Weakness does not occur by 6 months of Skin lesions is known as

Answer 9

AMYOPATHIC DERMATOMYOSITIS

Question 10

Acute PRESENTATION of DERMATOMYOSITIS

Answer 10

Pain and Weakness for Weeks to Months
In 30% pts

Question 11

Difference between Gottron’s papules and Gottron’s Rash

Answer 11

Anything other than a papules in place of Gottron’s papules

Question 12

Calcinosis Cutis seen in

Answer 12

1. Systemic Sclerosis
2. Juvenile DERMATOMYOSITIS

Question 13

Pathognomic SIGNS in DERMATOMYOSITIS

Answer 13

1. Gottron papules
2. Heliotrope Rash

Question 14

Signs seen in DERMATOMYOSITIS
Less-SPECIFIC

Answer 14

1. Gottron’s sign
2. Photo sensitivity
3. V sign
4. Shawl sign
5. Holster sign
6. Nail fold capillary changes with cuticular overgrowth
7. Pruritic Scalp Involvement
8. Mechanic Hand
9. Calcinosis cutis

Question 15

EMG in INFLAMMATORY MUSCLE DISEASE

Answer 15

⭐ Polyphasic Short Duration Small Amplitude Potentials

⭐ High frequency discharges

⭐ Spontaneous activity like fibrillation or Denervation

Question 16

Classical FINDING in DERMATOMYOSITIS

Answer 16

Peri-vascular lymphocytic infiltrates
➕
Peri-Fasicular Atrophy
➕
No NECROSIS

Question 17

In Juvenile DERMATOMYOSITIS always rule out

Answer 17

Malignancy of Ovary and Lung

Question 18

DERMATOMYOSITIS like weakness ⛔ Skin lesion
➕
Late Presentation 50-60yrs
➕
Necrosis ➕ at BIOPSY (But NO ATROPHY)

Answer 18

POLYMYOSITIS

Question 19

Antibodies seen in DERMATOMYOSITIS and POLYMYOSITIS

Answer 19

⭐ anti Jo1 (anti-synthetase)

Question 20

Anti-Jo1 ➕ INCREASR THE RISK OF
(Anti-Synthetase)

Answer 20

1. Mechanic’s HAND
2. Interstitial LUNG Disease: NSIP
3. Raynaud’s phenomena
4. Arthritis: SLE-like

Question 21

Which SKIN MANIFESTATION is seen in Both POLYMYOSITIS and DERMATOMYOSITIS

Answer 21

Mechanic’s Hand

Question 22

Anti-Mi2
Seen in

Answer 22

DERMATOMYOSITIS without ILD
GOOD PROGNOSIS

Question 23

Anti-SRP is ASSOCIATED with

Answer 23

Immune-mediated Necrotizing MYOPATHY

ASSOCIATED with statin use

Question 24

Antibody that indicates
✨ RAPID SKIN Involvement
✨ ILD

Answer 24

Anti MDA5

Question 25

Antibodies ASSOCIATED with

⭐ Cancer associated DERMATOMYOSITIS
⭐ Juvenile DERMATOMYOSITIS

Answer 25

Anti-TIF 1GAMMA
Anti-NxP2 (anti nuclear matrix protein 2)