GBS

Question 1

GBS
Distinguishing Feature
🧠⚡Guillian LL is silent⚡

Answer 1

NEUROLOGICAL EMERGENCY
⭐ ACUTE ONSET (Less than 4 weeks)
⭐ ASCENDING PARALYSIS
⭐ B/L
⭐ DEMYELINATING CONDITION
⭐ POLYRADICULO-NEUROPATHY

Question 2

Gullian Barre Syndrome
🧠⚡2 Gu-Baare : Left together ➡️ ascend upwards⚡

Answer 2

✨ Ascending symmetrical paralysis
✨ Axonal degeneration and Demyelination
✨ Respirator Failure

Question 3

🧑🏻‍⚕️ Clinical Features of GBS
🧠⚡ABCD ⚡

Answer 3

✨ ABCD: AlBumino-Cytological Dissociation
✨AFP
✨ Bladder incontinence
✨ Cranial Nerve Palsies
✨ DTR lost

Question 4

LAUNDRY’S PARALYSIS seen in

Answer 4

GBS

Question 5

Antibodies in Different types of GBS
🧠⚡ M ke sath M nhi⚡
🧠⚡ IIM⚡

Answer 5

Question 6

MILLER FISHER SYNDROME
🧠⚡IMAGINE A fish TAKEN OUT of water⚡

Answer 6

Question 7

Average Age Of onset of GBS

Answer 7

40 yrs

Question 8

AIDP: Pathology

Answer 8

Demyelinating

⭐ 1st ATTACK on Schwann Cells

Question 9

AXONAL Varients of GBS
Pathology

Answer 9

⭐ AMAN
⭐ AMSAN
Pathology: 1st ATTACKS on NODES OF RANVIER

⭐ Miller Fisher Syndrome

Question 10

RUBBERY LEGS
➕
TINGLING and DYSESTHESIA of LOWER LIMB
➕
ANS MANIFESTATIONS Prominent
➕
Rapidly Progressive B/L areflexic ASCENDING FLACCID PARALYSIS
➕
Mild TRANSIENT BLADDER DYSFUNCTION

Answer 10

GBS

Question 11

Fibers affected 1st in GBS

Answer 11

Large FIBER NEUROPATHY
Both Distal ➕ Proximal

Question 12

ANS Manifestations in GBS

Answer 12

⭐ BP fluctuations
⭐ Postural Hypotension
⭐ Arrhythmia
⭐ Deep aching pain in affected muscle

Question 13

Trigger infection of GBS
🧠⚡MECH ⚡

Answer 13

✨ Campylobacter jejuni
✨ CMV
✨ EBV
✨ Mycoplasma
✨ Hepatitis A, B
✨ HIV
✨ Post-immunization

Question 14

Mechanism of CAMPYLOBACTER JEJUNI in GBS

Answer 14

Molecular mimicry with MYELIN

Question 15

⚡⚡ MOST COMMON CRANIAL NERVE INVOLVED in GBS

Answer 15

7th CN Palsy B/L LMN palsy
⬇️
3rd CN Palsy B/L LMN palsy

Question 16

Recovery in GBS

Answer 16

Complete
⭐ By 2-4 weeks

Question 17

Most SENSITIVE Test in Evaluating GBS

Answer 17

Nerve Conduction Studies

Question 18

Albumino-Cytological dissociation is seen after

Answer 18

⭐ GBS

1 week of Disease

Question 19

💊💉 MANAGEMENT of GBS

Answer 19

⭐ IVIG 0.4gm/kg x 5 days
(OR)
⭐ PLEX 5 cycles

Question 20

Mortality increases in GBS if

Answer 20

Cranial nerve involvement

Question 21

Corticosteroids in GBS

Answer 21

Should NOT BE USED

Question 22

Diseases requiring Therapeutic Plasmaphersis
🧠⚡CAMP TAR ⚡

Answer 22

1. CIDP
2. AIDP
3. Myasthenia Gravis
4. Posts transfusion purpura
5. TTP
6. Anti-GBM disease
7. Refsum’s disease

Question 23

Descending Paralysis seen in
🧠⚡ BaD P²T⚡

Answer 23

1. Botulism (symmetrical)
2. Diphtheria
3. Polio
4. Porphyria
5. Tetanus

Question 24

Ascending Paralysis is seen in

Answer 24

GBS (Symmetrical)

Question 25

CIDP
Chronic Inflammatory Demyelination Polyradiculo-neuropathy
Cause

Answer 25

💡onset > 2 months
⭐ PRIMARY

⭐ SECONDARY
✨ HIV
✨ HODGKIN’S DISEASE
✨ PLASMA CELL DISORDER:
-MULTIPLE MYELOMA
-POEMS Syndrome

Question 26

Varients of CIDP
➕
Muscle atrophy like ALS
➕
anti-GM1 Demyelinating condition
➕
Affects ARMS > > > LEGS

Answer 26

MMN-CB: Multi-focal Motor NEUROPATHY with CONDUCTION BLOCK

Question 27

POEMS SYNDROME

Answer 27

✨ Polyradiculo-neuropathy: CIDP
✨ Organomegaly
✨ Endocrinopathy
✨ Multiple myeloma (Monoclonal Gammopathy)
-Osteosclerotic Lesions
-refractory to therapy
✨ Skin changes

Question 28

Elevated VEGF
➕
Associated with CASTLEMAN’S DISEASE

Answer 28

POEMS Syndrome

Question 29

AIDP vs CIDP

Answer 29

Question 30

Pure Motor NEUROPATHY
🧠⚡ LDM⚡

Answer 30

⭐ Lead
⭐ Dapsone
⭐ Multi-focal Motor NEUROPATHY with CONDUCTION block

Question 31

Nerve Biopsy is indicated in CIDP

Answer 31

⭐ Diagnosis is not clear
⭐ Other causes of Polyneuropathy cannot be ruled out
⭐ EMG shows AXONAL involvement

Question 32

Biopsy usually is NOT INDICATED in

Answer 32

Completely degenerated nerves usually convey limited information