Brainstem SYNDROMES Flashcards
Rule of 4 in Brainstem
4 CN arise from Cerebrum & Midbrain: 1,2,3,4
4 CN arise from PONS: 5,6,7,8
4 CN arise from Medulla: 9,10,11,12
Only Cranial Nerve to arise from DORSAL Aspect of MIDBRAIN
Cranial Nerve 4
Which Cranial nerves arise from Midline
🧠⚡ Rule of 12; Number whose multiple is 12⚡
3,4,6,12
Which Cranial nerves arise from Lateral Part of Brainstem
5,7,8,9,10,11
MEDIAL LONGITUDINAL FASICULUS
(MLF) connects
🧠⚡SEX with 3 others ⚡
6th CN with C/L 3rd CN nucleus
In Any Brainstem Syndrome, most Characteristic is
CROSSED HEMIPLEGIA
⭐ MIDBRAIN is supplied by
⭐ PONS is supplied by
⭐ MEDULLA is supplied by
⭐ MIDBRAIN is supplied by
🎯 P1 of Posterior Cerebral Artery (PCA)
⭐ PONS is supplied by
🎯 Medial Pontine: BASILAR Artery
🎯 Lateral Pontine: AICA
⭐ MEDULLA is supplied by
🎯 MEDIAL MEDULLARY: Anterior Spinal Artery
🎯 LATERAL MEDULLARY: PICA
Midbrain @ SUPERIOR COLLICULUS
🧠⚡Only MIDBRAIN Cross section to be remembered ⚡
Midbrain section @ INFERIOR COLLICULUS
How to differentiate Superior & Inferior COLLICULUS
At Superior COLLICULUS: 3rd CN seen
At Inferior COLLICULUS: 4th CN seen
Midline structures of BRAINSTEM
🧠⚡4M⚡
🧠⚡Midline = Motor ⚡
✨ Motor CN 3,4,6,12
✨ Medial Longitudinal FASICULUS
✨ Medial Leminiscus ➡️ DCML ➡️ VIBRATION & PROPRIOCEPTION
✨ Motor Fibers of Corticospinal Tract ➡️ C/L HEMIPLEGIA
Lateral structures of BRAINSTEM
🧠⚡4S⚡
🧠⚡Sides = Sensory ⚡
- Spinocerebellar Fibers ➡️ ATAXIA
- Spinal Leminiscus (Spinothalamic Tract) ➡️ Carry PAIN & TEMPERATURE from OPPOSITE SAIDE
- Spinal nucleus of Trigeminal nerve
- Sympathetic Fibers ➡️ HORNER’S Syndrome
- CN 5,7,9,10,11
Midbrain Syndromes
🧠⚡all have I/L 3rd CN Palsy ⚡
Ventral Midbrain
1. Weber’s
2. Benedikt’s
3. Claude
Dorsal Midbrain
4. Parinaud
5. Nothnagel
I/L Occulomotor Nerve Palsy
➕
C/L Hemiplegia
Weber’s syndrome
I/L Occulomotor Nerve Palsy
➕
C/L Bobbing Head Movement (Red Nucleus Involvement) or C/L ATAXIA
➕
C/L HEMIBALLISMUS
🧠⚡B for B⚡
Benedikt’s Syndrome
NOTHNAGEL Syndrome
🧠⚡North is Superior ⚡
🧠⚡noThnagel ⚡
TECTUM Involvement ➕
✨ Ataxia
✨ Paralysis of Gaze
CLAUDE Syndrome
🧠⚡C = Combination ⚡
🧠⚡BNC⚡
Combination of Benedikt’s ➕ NOTHNAGEL syndrome
PARINAUD’S SYNDROME
🧠⚡ParinauD ⚡
✨ Pineal Gland related Tumour
Involves 2P:
🎯 Pretectal Nucleus
🎯 Periaqueductal Gray Matter
✨ Dorsal Part Compression (contain Superior COLLICULUS)
⬇️
Superior Gaze Palsy
Sunset sign
Skew Deviation
Collier’s sign
SUNSET sign seen in
- PARINAUD’S SYNDROME
- Hydrocephalus
Collier’s Sign is seen in
PARINAUD’S SYNDROME
✨ Lid Retraction
⚡⚡ MOST COMMON MIDBRAIN SYNDROME
Weber’s SYNDROME
PONTINE SYNDROMES
🧠⚡MRF Locked In⚡
- MILLARD GUBLER SYNDROME
- RAYMOND SYNDROME
- FOVILLE Syndrome
- Locked in Syndrome
Cranial Nerves arising from PONTOMEDULLARY JUNCTION
6,7,8
If Cranial nerves 6, 7, 8 lesioned, lesion lies at
Lower Level of Pons
Millard GUBLER SYNDROME
🧠⚡ 7 letters & 6 letters⚡
6th & 7th CN palsy
Spares the NUCLEUS only affects the Nerve Fibers
FOVILLE SYNDROME
🧠⚡ 7 letters⚡
7th CN Palsy
➕
Lateral Gaze Palsy
RAYMOND Syndrome
🧠⚡Ond = 1 nerve only ⚡
6th CN affected
LOCKED IN SYNDROME
B/L Ventral PONTINE Involvement
Medial Medullary Syndrome
Synonym
Dejerine Syndrome
Features of DEJERINE Syndrome
🧠⚡4M⚡
- Cranial Nerve 12 affected ➡️ Gets DEVIATED to same side
- Medial Leminiscus affected ➡️ C/L Proprioception Loss
- Motor Corticospinal Tract affected ➡️ C/L Hemiplegia
- MLF lesion ➡️ Intranuclear Opthalmoplegia
⭐ PICA Involvement leads to
⭐ AICA Involvement leads to
⭐ PICA Involvement leads to
🎯 Lateral Medullary Syndrome
⭐ AICA Involvement leads to
🎯 Lateral Pontine Syndrome
AICA Involvement
🧠⚡fACIAl⚡
7th CN palsy
➕
SNHL (DUE TO: Labyrinthine artery Involvement)
Wallenberg syndrome
Synonyms
✨ Lateral Medullary Syndrome
✨ PICA syndrome
Features of Wallenberg Syndrome
🧠⚡ 5S⚡
- Spinal Nucleus of Trigeminal Nerve ( 5th CN) affected ➡️ I/L Face Sensation Lost
- Nucleus Tractus Solitarius affected ( 7th CN) ➡️ Loss of Taste in Anterior ⅔rd of Tongue
- Nucleus ambiguus affected ( 9th & 10th CN) ➡️ Palatal Palsy, Dysphagia, Hoarseness, Nasal Regurgitation
- Spinocerebellar fibers affected ➡️ I/L Ataxia
- Spinothalamic Fibers affected ➡️ C/L Pain & Temperature
- Sympathetic abnormalities
PICA Involvement
🧠⚡PICAchew ⚡
Chewing Difficulty ➡️ Dysphagia in Lateral Medullary Syndrome
Identify
Medulla Oblongata Cross Section
Identify
Weber Syndrome
Identify
Benedikt’s Syndrome
Identify
Claude’s symdrome
Causes of ARGYLL ROBERTSON PUPIL
- Neurosyphilis
- PARINAUD’S SYNDROME
Pretectal Nucleus is responsible for
Light Reflex Pathway
ARGYLL ROBERTSON PUPIL
🧠⚡ ARP , PRA⚡
Accomodation Reflex Present
Positive Light Reflex Absent
Marie Foix Syndrome
Lateral Pontine Syndrome
Avellis Syndrome
10th CN ➡️ Paralysis of Soft Palate & Vocal Cord
➕
Spinothalamic Tract ➡️ C/L Hemianesthesia
Site of AVELLIS Syndrome & Jackson Syndrome
Tegmentum of Medulla
Jackson Syndrome
Avellis syndrome
➕
I/L 12th CN palsy ➡️ Tongue Syndrome
Cruciate Paralysis
Meaning
Arm weakness on 1 SIDE
➕
Leg Weakness on Other SIDE
⚡⚡ MOST COMMON CAUSE OF LATERAL MEDULLARY Syndrome
V4 Segment of VERTEBRAL ARTERY > PICA
Pseudo Abducent Nerve Palsy seen in
⭐ CAUSE
Parinaud’s syndrome
Cause: CONVERGENT CENTER Overactivity
Convergent Refractive Nystagmus seen in
Parinaud’s syndrome
⭐ Parinaud’s Syndrome is Caused DUE TO:
⭐ Parinaud’s Occuloglandular Syndrome is Caused DUE TO:
⭐ Parinaud’s Syndrome is Caused DUE TO:
🎯 Pinealoma
⭐ Parinaud’s Occuloglandular Syndrome is Caused DUE TO:
🎯 Francisella Tularensis (Tularemia)
Cause of COLLIER’S Sign
Overactive LPS
⬇️
DUE TO: End neurons
Everything is lost I/L in WALLENBURG Syndrome, except
C/L Pain & Temperature
Spinothalamic Fibers
What is considered as Cranial Nerve 13
Sympathetic chain
Which Lateral Nerve is spared in WALLENBURG Syndrome
CN 11
LOCATED VERY DOWN