Inflammation and wound healing (E1) Flashcards
First line of defense
non specific and not activates/ deactivated
second line of defense
non-specific, activated as needed. Inflammation with non specific white blood cells
third line of defense
specific immunity, activated as needed. with T- cells and b- cells
what is inflammation
a non-specific localized response to injury
clinical manifestation of inflammation
pain, redness, swelling, heat, temporary loss of function
exudate
fluid that flows in a area of irritation, causes swelling
serous exudate
fluid inside blisters (clear)
fibrinous exudate
cloudiness in fluid
purulent exudate
abscess full of pus
hemorrhagic exudate
blood into area of inflammation
granulomas
can form with inflammation, encapsulates pathogen or foreign object
what happened during an inflammatory response (chemical)
degranulation of mast cells which releases histamine, WBC chemotactic factors, and long term response chemicals
Histamine
stored in cytoplasmic granules, a vasodilator
white blood cells chemotactic factors
attract wbcs to areas
Long term inflammatory chemical response
prostaglandins and leukotrienes. Maintain rather than initiate inflammation
complement system
plasmas proteins that target foreign invaders
clotting system
coagulation, increases blood clotting
Inflammation phases
vasodilation, phagocyte migration, repair
vasodilation
blood vessels get wider with an increases in tissue permeability and an influx of exudate
margination and pavementing
WBC sense chemotactic factors and stick against blood vessel wall
diapedesis
phagocytes squeeze between blood vessel/ tissue cells to reach where chemotactic factor is strongest
regeneration (tissue)
made as it was before including structure and function
repair (tissue)
with more extensive
damage, scar tissue that may mean not all structure or function returned
reconstructive (tissue)
happens first, focuses on rebuilding, adding cells, and actual structure
