Inflammation 6: Chemical mediators of inflammations Flashcards
inflammatory mediators responsible for Vasodilatation
- Histamine
- Prostaglandins
- Nitric oxide
inflammatory mediators responsible for Inceased vascular permiablilty
- Histamine
- Bradykinin
- C3a
- C5a
- Leukotriens
inflammatory mediators responsible for Chemotaxis
- Tissue Necrotic factor (TNF)
- C3a
- C5a
- IL 1
- LTB4
inflammatory mediators responsible for pain
- PGE2
- Bradykinin
inflammatory mediators responsible for tissue damage
- ROS
- lysosomes
inflammatory mediators responsible for Fever
- PGs
- IL1
- TNF
inflammatory mediators responsible for leukocyte activation & adhesion
- cytokines
- IL1
- LTs
- C5a
- TNF
- toxins
Plasma derived mediators are ____ by default, and activated by ____
- Inactive
- Proteolysis (tissue damage)
Plasma derived mediators are divided into
CBC:
* Complement
* Bradykinin
* Coagulation factors
function of C3a & C5a together
induce mast cells to secrete histamine (increase VD and permiability)
function of C5a alone
- chemotaxis
- adhesion
- activation
function of C3b
opsonisation
function of C9
killing of bacteria by MAC (membrane attacking complex)
cell derived mediators are divided into
- Vasoactive amines (first mediators)
- Arachidonic acid metabolites (PGs LTs)
- Cytokines
- ROS
- NO
- lysosomal enzymes
Histamine is inactivated by
histaminase
found in eosinophils (cells responding to allergic reactions)
function of serotonin in injury
Vasoconstriction during clotting
realeased from platelets
Function of NO in inflammation
- Vasodilatation
- reduce recruitment
enzyme found in intact cells at inflammatory site that limit their damage from lysosomal enzymes
antiproteases
(alpha 1 antitrypsin)
