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INT 208: Pathology > Inflammation 6: Chemical mediators of inflammations > Flashcards

Inflammation 6: Chemical mediators of inflammations Flashcards

1
Q

inflammatory mediators responsible for Vasodilatation

A
  • Histamine
  • Prostaglandins
  • Nitric oxide
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2
Q

inflammatory mediators responsible for Inceased vascular permiablilty

A
  • Histamine
  • Bradykinin
  • C3a
  • C5a
  • Leukotriens
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3
Q

inflammatory mediators responsible for Chemotaxis

A
  • Tissue Necrotic factor (TNF)
  • C3a
  • C5a
  • IL 1
  • LTB4
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4
Q

inflammatory mediators responsible for pain

A
  • PGE2
  • Bradykinin
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5
Q

inflammatory mediators responsible for tissue damage

A
  • ROS
  • lysosomes
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6
Q

inflammatory mediators responsible for Fever

A
  • PGs
  • IL1
  • TNF
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7
Q

inflammatory mediators responsible for leukocyte activation & adhesion

A
  • cytokines
  • IL1
  • LTs
  • C5a
  • TNF
  • toxins
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8
Q

Plasma derived mediators are ____ by default, and activated by ____

A
  • Inactive
  • Proteolysis (tissue damage)
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9
Q

Plasma derived mediators are divided into

A

CBC:
* Complement
* Bradykinin
* Coagulation factors

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10
Q

function of C3a & C5a together

A

induce mast cells to secrete histamine (increase VD and permiability)

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11
Q

function of C5a alone

A
  • chemotaxis
  • adhesion
  • activation
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12
Q

function of C3b

A

opsonisation

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13
Q

function of C9

A

killing of bacteria by MAC (membrane attacking complex)

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14
Q

cell derived mediators are divided into

A
  • Vasoactive amines (first mediators)
  • Arachidonic acid metabolites (PGs LTs)
  • Cytokines
  • ROS
  • NO
  • lysosomal enzymes
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15
Q

Histamine is inactivated by

A

histaminase

found in eosinophils (cells responding to allergic reactions)

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16
Q

function of serotonin in injury

A

Vasoconstriction during clotting

realeased from platelets

17
Q

Function of NO in inflammation

A
  • Vasodilatation
  • reduce recruitment
18
Q

enzyme found in intact cells at inflammatory site that limit their damage from lysosomal enzymes

A

antiproteases
(alpha 1 antitrypsin)

INT 208: Pathology (27 decks)

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