Infectious hepatitis

Question 1

Why can Hep A virus infect the gut so easily?

Answer 1

can withstand low pH

Question 2

Hep A transmission route

Answer 2

fecal-oral

Question 3

when high concentrations of viruses are shed in Hep A

Answer 3

3-10 days prior and just after clinical sx show

Question 4

abrupt transision from well to illness

Answer 4

Hep A

Question 5

gen sx of viral Hep (all strands)

Answer 5

RUQ pain

fever, malaise, myalgia, anorexia, N/V

Question 6

what actually makes you sick in Hep A infection

Answer 6

immune response

Question 7

dx for Hep A

Answer 7

IgM antibody against Hep A

Question 8

Hep A endemic areas

Answer 8

worldwide

Question 9

critical control measure for Hep A

Answer 9

handwashing after bowel movements and before food prep

Question 10

transmission fof Hep E

Answer 10

fecal oral

Question 11

10X more mortal than Hep A

Answer 11

hep E

Question 12

serious risk population of Hep E

Answer 12

pregnant women

Question 13

range of Hep E

Answer 13

worldwde, byt more serious risk in developing nations

Question 14

primararly transferred by blood or blood products

Answer 14

Hep B

Question 15

phase of Dane particle that is infectious

Answer 15

mature

Question 16

forms Dane particles

Answer 16

Hep B

Question 17

how is Hep B replication unique

Answer 17

involves DNA virus going through RNA intermediate using reverse transcriptidase

Question 18

Hep strain that can cause cancer

Answer 18

Hep B

Question 19

how can Hep B cause cancer

Answer 19

intergrates genome into chromosomal DNA of liver cells

Question 20

sexually transmitted Hep

Answer 20

B

Question 21

pathology cause of Hep B

Answer 21

cellularimmune response to viral antigens in the liver

Question 22

1% of Hep B will progress to

Answer 22

severe fulminant hepatitis (often fatal)

Question 23

defeinition of chronic Hep B

Answer 23

HBsAg found in the bloof for 6 months in the absence of detectable antibody

Question 24

polyateritis nodusum and glomerulonephritis

Answer 24

chronic perisitant Heb B

Question 25

marker of immunity to Heb B

Answer 25

precense of antibody to HBsAg

Question 26

dx of Hep B

Answer 26

HBsAg in blood of individual presenting with acute hep sx

Question 27

most important feature of HBV infection of the newborn

Answer 27

chronicity

Question 28

control measures against Hep B

Answer 28

vaccination of high risk groups
immune globulin when needed
selection and screening of blood donors
education of healthcare workers and other high risk groups

Question 29

treatment of chronic Hep B

Answer 29

alpha-interferon and lamivudine

Question 30

Hep D needs what to be replicate

Answer 30

Hep B

Question 31

important cause of fulminant hepatitis

Answer 31

Hep D

Question 32

acute Hep B and antibody to Hep D

Answer 32

Hep D co-infection

Question 33

sudden deteriioration in health of Hep B pt with ABsAg carrier state

Answer 33

Heb D superinfection

Question 34

dx of chronic delta hep

Answer 34

HBsAg and high titers of antibody to HDV antigen

Question 35

tranmission of Hep C

Answer 35

blood and blood products

Question 36

dx of Hep C

Answer 36

ELISA and western blot

Question 37

treatment of Hep C

Answer 37

pegelated interferon alpha and ribavarin