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GI > Infectious hepatitis > Flashcards

Infectious hepatitis Flashcards

1
Q

Why can Hep A virus infect the gut so easily?

A

can withstand low pH

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2
Q

Hep A transmission route

A

fecal-oral

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3
Q

when high concentrations of viruses are shed in Hep A

A

3-10 days prior and just after clinical sx show

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4
Q

abrupt transision from well to illness

A

Hep A

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5
Q

gen sx of viral Hep (all strands)

A

RUQ pain

fever, malaise, myalgia, anorexia, N/V

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6
Q

what actually makes you sick in Hep A infection

A

immune response

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7
Q

dx for Hep A

A

IgM antibody against Hep A

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8
Q

Hep A endemic areas

A

worldwide

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9
Q

critical control measure for Hep A

A

handwashing after bowel movements and before food prep

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10
Q

transmission fof Hep E

A

fecal oral

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11
Q

10X more mortal than Hep A

A

hep E

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12
Q

serious risk population of Hep E

A

pregnant women

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13
Q

range of Hep E

A

worldwde, byt more serious risk in developing nations

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14
Q

primararly transferred by blood or blood products

A

Hep B

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15
Q

phase of Dane particle that is infectious

A

mature

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16
Q

forms Dane particles

A

Hep B

17
Q

how is Hep B replication unique

A

involves DNA virus going through RNA intermediate using reverse transcriptidase

18
Q

Hep strain that can cause cancer

A

Hep B

19
Q

how can Hep B cause cancer

A

intergrates genome into chromosomal DNA of liver cells

20
Q

sexually transmitted Hep

A

B

21
Q

pathology cause of Hep B

A

cellularimmune response to viral antigens in the liver

22
Q

1% of Hep B will progress to

A

severe fulminant hepatitis (often fatal)

23
Q

defeinition of chronic Hep B

A

HBsAg found in the bloof for 6 months in the absence of detectable antibody

24
Q

polyateritis nodusum and glomerulonephritis

A

chronic perisitant Heb B

25
Q

marker of immunity to Heb B

A

precense of antibody to HBsAg

26
Q

dx of Hep B

A

HBsAg in blood of individual presenting with acute hep sx

27
Q

most important feature of HBV infection of the newborn

A

chronicity

28
Q

control measures against Hep B

A

vaccination of high risk groups
immune globulin when needed
selection and screening of blood donors
education of healthcare workers and other high risk groups

29
Q

treatment of chronic Hep B

A

alpha-interferon and lamivudine

30
Q

Hep D needs what to be replicate

A

Hep B

31
Q

important cause of fulminant hepatitis

A

Hep D

32
Q

acute Hep B and antibody to Hep D

A

Hep D co-infection

33
Q

sudden deteriioration in health of Hep B pt with ABsAg carrier state

A

Heb D superinfection

34
Q

dx of chronic delta hep

A

HBsAg and high titers of antibody to HDV antigen

35
Q

tranmission of Hep C

A

blood and blood products

36
Q

dx of Hep C

A

ELISA and western blot

37
Q

treatment of Hep C

A

pegelated interferon alpha and ribavarin

GI (22 decks)

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